User profiles for "author:M Flather"

Marcus Flather

University of East Anglia
Verified email at uea.ac.uk
Cited by 107128

Long-term ACE-inhibitor therapy in patients with heart failure or left-ventricular dysfunction: a systematic overview of data from individual patients

MD Flather, S Yusuf, L Køber, M Pfeffer, A Hall… - The Lancet, 2000 - thelancet.com
Background We undertook a prospective systematic overview based on data from individual
patients from five long-term randomised trials that assessed inhibitors of angiotensin …

ACC/AHA/ESC guidelines for the management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association Task Force …

…, G De Backer, M Flather… - Journal of the American …, 2001 - jacc.org
Atrial fibrillation (AF) is the most common sustained rhythm disturbance. Its prevalence is
increasing along with the age of the population. AF is often associated with structural heart …

American College of Cardiology/European Society of Cardiology clinical expert consensus document on hypertrophic cardiomyopathy: a report of the American …

…, G De Backer, J Deckers, M Flather… - Journal of the American …, 2003 - jacc.org
Writing Committee consisted of acknowledged experts in hypertrophic cardiomyopathy
(HCM) representing the American College of Cardiology Foundation and the European …

[HTML][HTML] Antiinflammatory therapy with canakinumab for atherosclerotic disease

…, Z Kobalava, L Vida-Simiti, M Flather… - New England journal …, 2017 - Mass Medical Soc
Background Experimental and clinical data suggest that reducing inflammation without
affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory …

[HTML][HTML] Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events

DL Bhatt, KAA Fox, W Hacke, PB Berger… - … England Journal of …, 2006 - Mass Medical Soc
Background Dual antiplatelet therapy with clopidogrel plus low-dose aspirin has not been
studied in a broad population of patients at high risk for atherothrombotic events. Methods …

Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure (SENIORS)

MD Flather, MC Shibata, AJS Coats… - European heart …, 2005 - academic.oup.com
Aims Large randomized trials have shown that beta-blockers reduce mortality and hospital
admissions in patients with heart failure. The effects of beta-blockers in elderly patients with …

A validated prediction model for all forms of acute coronary syndrome: estimating the risk of 6-month postdischarge death in an international registry

KA Eagle, MJ Lim, OH Dabbous, KS Pieper… - Jama, 2004 - jamanetwork.com
ContextAccurate estimation of risk for untoward outcomes after patients have been
hospitalized for an acute coronary syndrome (ACS) may help clinicians guide the type and …

Predictors of hospital mortality in the global registry of acute coronary events

CB Granger, RJ Goldberg, O Dabbous… - Archives of internal …, 2003 - jamanetwork.com
Background Management of acute coronary syndromes (ACS) should be guided by an
estimate of patient risk. Objective To develop a simple model to assess the risk for in …

Efficacy and safety of dabigatran compared with warfarin at different levels of international normalised ratio control for stroke prevention in atrial fibrillation: an analysis …

…, S Yusuf, MD Ezekowitz, M Alings, M Flather… - The Lancet, 2010 - thelancet.com
Background Effectiveness and safety of warfarin is associated with the time in therapeutic
range (TTR) with an international normalised ratio (INR) of 2· 0–3· 0. In the Randomised …

Effect of interleukin-1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind …

…, M Donath, JJ Hwang, H Kultursay, M Flather… - The Lancet, 2017 - thelancet.com
Background Inflammation in the tumour microenvironment mediated by interleukin 1β is
hypothesised to have a major role in cancer invasiveness, progression, and metastases. We …