Lipids are vital components of many biological processes and crucial in the pathogenesis of
numerous common diseases, but the specific mechanisms coupling intracellular lipids to …

Over the past decade, evidences of an integration of metabolic and inflammatory pathways,
referred to as metaflammation in several aspects of metabolic syndrome, have been …

Xanthine oxidoreductase (XOR) consists of two different forms, xanthine dehydrogenase
and xanthine oxidase (XO), and is a rate-limiting enzyme of uric acid production from …

Endoplasmic reticulum (ER) stress is a key link between obesity, insulin resistance, and type
2 diabetes. Here, we provide evidence that this mechanistic link can be exploited for …

Adipocyte fatty-acid-binding protein, aP2 (FABP4) is expressed in adipocytes and
macrophages, and integrates inflammatory and metabolic responses. Studies in aP2 …

Adiponectin, an adipocyte-derived protein, has been suggested to play an important role in
insulin sensitivity. We examined the association between insulin sensitivity (M value) …

A molecular phylogenetic analysis of 25 isolates of fish nodaviruses, the causative agents of
viral nervous necrosis of marine fish, was performed based on the nucleotide sequences …

As chronic inflammation is a hallmark of obesity, pathways that integrate nutrient-and
pathogen sensing pathways are of great interest in understanding the mechanisms of insulin …

Fatty acid binding proteins (FABPs) are cytosolic fatty acid chaperones whose biological role
and mechanisms of action are not well understood. Here, we developed mice with targeted …

BACKGROUND Angiotensin-converting enzyme 2 (ACE2) is highly expressed in the kidney
and converts angiotensin (Ang) II to Ang-(1–7), a renoprotective peptide. Urinary ACE2 has …