The wealth of distinct enzymatic functions found in nature is impressive and the on‐going
evolutionary divergence of enzymatic functions continues to generate new and efficient …

Very small but cumulated decreases in food intake may be sufficient to erase obesity over a
period of years. We examine the effect of slight changes in the accessibility of different foods …

Enzymes must be ordered to allow the stabilization of transition states by their active sites,
yet dynamic enough to adopt alternative conformations suited to other steps in their catalytic …

The POWER8™ processor is the latest RISC (Reduced Instruction Set Computer)
microprocessor from IBM. It is fabricated using the company's 22-nm Silicon on Insulator …

Twenty-two patients with hypertrophic obstructive cardiomyopathy were treated with the
calcium inhibitor, verapamil, which was administered in a mean oral dose of 480 mg per …

The application of nigrosin as a stain for differentiating between live cells with unchanged
membranes and cells whose membranes have been modified either experimentally or by …

The emergence of catalysis in a noncatalytic protein scaffold is a rare, unexplored event.
Chalcone isomerase (CHI), a key enzyme in plant flavonoid biosynthesis, is presumed to …

The aim of this study was to evaluate subjective noise perception and objective parameters
of circulation in the vicinity of the Frankfurt airport. Two areas were selected in which aircraft …

Vinblastine and vincristine are two medically important bisindole alkaloids from
Catharanthus roseus (Madagascar periwinkle). Attempts at production in cell cultures failed …

Ancestral reconstruction provides instrumental insights regarding the biochemical and
biophysical characteristics of past proteins. A striking observation relates to the remarkably …