Diabetes is associated with changes in plasma lipids and lipoproteins into atherogenic
direction. In IDDM these changes are small or absent if good metabolic control can be …

Cardiovascular disease (coronary heart disease, stroke, peripheral vascular disease) is the
most important cause of mortality and morbidity among patients with type 2 diabetes …

The prevalence of diabetes mellitus will likely increase globally from 371 million individuals
in 2013 to 552 million individuals in 2030. This epidemic is mainly attributable to type 2 …

Large-scale reference data sets of human genetic variation are critical for the medical and
functional interpretation of DNA sequence changes. Here we describe the aggregation and …

Background Patients with type 2 diabetes mellitus are at increased risk of cardiovascular
disease, partly owing to dyslipidaemia, which can be amenable to fibrate therapy. We …

Background Type 2 diabetes mellitus is increasingly common, primarily because of
increases in the prevalence of a sedentary lifestyle and obesity. Whether type 2 diabetes …

Background Patients with type 2 diabetes are at high risk of fatal and non-fatal myocardial
infarction and stroke. There is indirect evidence that agonists of peroxisome proliferator …

Background Type 2 (non-insulin-dependent) diabetes is associated with a marked increase
in the risk of coronary heart disease. It has been debated whether patients with diabetes …

Genome-wide association (GWA) studies have identified multiple loci at which common
variants modestly but reproducibly influence risk of type 2 diabetes (T2D),,,,,,,,,,. Established …

By combining genome-wide association data from 8,130 individuals with type 2 diabetes
(T2D) and 38,987 controls of European descent and following up previously unidentified …