Prioritization of cancer therapeutic targets using CRISPR–Cas9 screens

…, G Migliardi, R Santos, Y Rao, F Sassi, M Pinnelli… - Nature, 2019 - nature.com
Functional genomics approaches can overcome limitations—such as the lack of
identification of robust targets and poor clinical efficacy—that hamper cancer drug …

EGFR Blockade Reverts Resistance to KRASG12C Inhibition in Colorectal Cancer

…, M Montone, B Mussolin, Y Bian, A Whaley, M Pinnelli… - Cancer discovery, 2020 - AACR
Most patients with KRAS G12C–mutant non–small cell lung cancer (NSCLC) experience
clinical benefit from selective KRASG12C inhibition, whereas patients with colorectal cancer …

Unusual CD4+CD28nullT Lymphocytes and Recurrence of Acute Coronary Events

…, LM Biasucci, G Trotta, S Brugaletta, M Pinnelli… - Journal of the American …, 2007 - jacc.org
Objectives: We hypothesized that the expansion of unusual T lymphocytes, CD4+
CD28nullT cells, might represent a key pathogenetic mechanism of recurrent instability …

Persistent activation of nuclear factor kappa-B signaling pathway in patients with unstable angina and elevated levels of C-reactive protein: evidence for a direct …

…, A Porto, S Brugaletta, M Pinnelli… - Journal of the American …, 2007 - jacc.org
Objectives: Our study investigated: 1) the contribution of nuclear factor kappa-B (NF-κB)
signaling pathway to the enhanced inflammatory response observed in unstable angina …

Skin ulcers in systemic sclerosis: determinants of presence and predictive factors of healing

…, A Mannocci, SL Bosello, G Peluso, M Pinnelli… - Journal of the American …, 2009 - Elsevier
BACKGROUND: Skin ulcers are common vascular complications of systemic sclerosis
(SSc). OBJECTIVE: The aim of the study was to identify clinical, biologic, and imaging …

Colorectal cancer residual disease at maximal response to EGFR blockade displays a druggable Paneth cell–like phenotype

B Lupo, F Sassi, M Pinnelli, F Galimi… - Science translational …, 2020 - science.org
Blockade of epidermal growth factor receptor (EGFR) causes tumor regression in some
patients with metastatic colorectal cancer (mCRC). However, residual disease reservoirs …

Endothelium and inflammation.

M Piro, G Giubilato, M Pinnelli, LM Biasucci - Panminerva medica, 2005 - europepmc.org
During the past decade, our understanding of the pathophysiology of coronary heart disease
(CAD) has undergone a remarkable evolution. To date atherosclerosis is considered an …

Bronchoalveolar lavage fluid and progression of scleroderma interstitial lung disease

…, SL Bosello, G Peluso, M Pinnelli… - The clinical …, 2012 - Wiley Online Library
Introduction: So far no clinical or experimental evidences clearly explain how and which
systemic sclerosis (SSc) patients will experience a functional and radiological progression of …

Novel anti-inflammatory effect of statins: reduction of CD4+ CD28null T lymphocyte frequency in patients with unstable angina

S Brugaletta, LM Biasucci, M Pinnelli, G Biondi-Zoccai… - Heart, 2006 - heart.bmj.com
METHODS Population We studied 111 consecutive patients (mean (SD) age 64 (9) years;
32 women) admitted to our coronary care unit with Braunwald class IIIB unstable angina: 33 …

[HTML][HTML] Wearable Systems for Unveiling Collective Intelligence in Clinical Settings

M Pulcinelli, M Pinnelli, C Massaroni, D Lo Presti… - Sensors, 2023 - mdpi.com
Nowadays, there is an ever-growing interest in assessing the collective intelligence (CI) of a
team in a wide range of scenarios, thanks to its potential in enhancing teamwork and group …