User profiles for "author:M Smyth"

Mark J. Smyth

- Verified email at qimrberghofer.edu.au - Cited by 135873

Michael Smyth

- Verified email at warwick.ac.uk - Cited by 8266

Natural innate and adaptive immunity to cancer

MD Vesely, MH Kershaw, RD Schreiber… - Annual review of …, 2011 - annualreviews.org
The immune system can identify and destroy nascent tumor cells in a process termed cancer
immunosurveillance, which functions as an important defense against cancer. Recently …

Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion

RD Schreiber, LJ Old, MJ Smyth - Science, 2011 - science.org
Understanding how the immune system affects cancer development and progression has
been one of the most challenging questions in immunology. Research over the past two …

New insights into cancer immunoediting and its three component phases—elimination, equilibrium and escape

D Mittal, MM Gubin, RD Schreiber, MJ Smyth - Current opinion in …, 2014 - Elsevier
Highlights•Genomics analyses to identify the targets of cancer immunoediting and design
personalized cancer immunotherapy.•Emerging role of innate immune cells (NK, DC …

Outcomes of a field trial to improve children's dietary patterns and physical activity: The Child and Adolescent Trial for Cardiovascular Health (CATCH)

…, M Reinhardt, R Sieving, J Smisson, M Smyth… - Jama, 1996 - jamanetwork.com
Objective.—To assess the outcomes of health behavior interventions, focusing on the
elementary school environment, classroom curricula, and home programs, for the primary …

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

F Ghiringhelli, L Apetoh, A Tesniere, L Aymeric, Y Ma… - Nature medicine, 2009 - nature.com
The therapeutic efficacy of anticancer chemotherapies may depend on dendritic cells (DCs),
which present antigens from dying cancer cells to prime tumor-specific interferon-γ (IFN-γ) …

European resuscitation council guidelines 2021: executive summary

…, EM Singletary, C Skare, MB Skrifvars, M Smyth… - Resuscitation, 2021 - Elsevier
Informed by a series of systematic reviews, scoping reviews and evidence updates from the
International Liaison Committee on Resuscitation, the 2021 European Resuscitation Council …

Adaptive immunity maintains occult cancer in an equilibrium state

CM Koebel, W Vermi, JB Swann, N Zerafa, SJ Rodig… - Nature, 2007 - nature.com
The capacity of immunity to control and shape cancer, that is, cancer immunoediting, is the
result of three processes,,,,,,, that function either independently or in sequence: elimination …

Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting

H Matsushita, MD Vesely, DC Koboldt, CG Rickert… - Nature, 2012 - nature.com
Cancer immunoediting, the process by which the immune system controls tumour outgrowth
and shapes tumour immunogenicity, is comprised of three phases: elimination, equilibrium …

[HTML][HTML] Tumor infiltrating lymphocytes are prognostic in triple negative breast cancer and predictive for trastuzumab benefit in early breast cancer: results from the …

S Loi, S Michiels, R Salgado, N Sirtaine, V Jose… - Annals of oncology, 2014 - Elsevier
Background We have previously shown the prognostic importance of tumor-infiltrating
lymphocytes (TILs) in newly diagnosed triple-negative breast cancer (TNBC) using tumor …

European resuscitation council guidelines for resuscitation 2015: section 1. Executive summary

KG Monsieurs, JP Nolan, LL Bossaert, R Greif… - Resuscitation, 2015 - Elsevier
This executive summary provides the essential treatment algorithms for the resuscitation of
children and adults and highlights the main guideline changes since 2010. Detailed …