User profiles for "author:M Spiecker"

Martin Spiecker

Karlsruhe Institute of Technology
Verified email at kit.edu
Cited by 500

Vascular protective effects of cytochrome p450 epoxygenase-derived eicosanoids

M Spiecker, JK Liao - Archives of biochemistry and biophysics, 2005 - Elsevier
Cytochrome P450 epoxygenases metabolize arachidonic acid to biologically active
eicosanoids. Primary epoxidation products are four regioisomers of cis-epoxyeicosatrienoic …

Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids

K Node, Y Huo, X Ruan, B Yang, M Spiecker, K Ley… - Science, 1999 - science.org
The epoxyeicosatrienoic acids (EETs) are products of cytochrome P450 epoxygenases that
have vasodilatory properties similar to that of endothelium-derived hyperpolarizing factor …

Risk of coronary artery disease associated with polymorphism of the cytochrome P450 epoxygenase CYP2J2

M Spiecker, H Darius, T Hankeln, M Soufi, AM Sattler… - Circulation, 2004 - Am Heart Assoc
Background—Cytochrome P450 (CYP) 2J2 is expressed in the vascular endothelium and
metabolizes arachidonic acid to biologically active epoxyeicosatrienoic acids (EETs). The …

Emergency angioplasty of totally occluded left main coronary artery in acute myocardial infarction and unstable angina pectoris—institutional experience and literature …

M Spiecker, R Erbel, HJ Rupprecht… - European heart …, 1994 - academic.oup.com
Acute occlusion of the left main coronary artery (LMCA) is a rare angiographic finding. We
report five patients with acute myocardial infarction (AMI) and one patient with unstable …

[HTML][HTML] Inhibition of endothelial vascular cell adhesion molecule-1 expression by nitric oxide involves the induction and nuclear translocation of IκBα

M Spiecker, HB Peng, JK Liao - Journal of Biological Chemistry, 1997 - ASBMB
The induction of vascular cell adhesion molecule-1 (VCAM-1) expression by tumor necrosis
factor (TNF)-α requires the activation of nuclear factor-κB (NF-κB) via a process involving the …

Lipophilic statins interfere with the inhibitory effects of clopidogrel on platelet function—a flow cytometry study

…, B Günesdogan, C Hanefeld, M Spiecker… - European Heart …, 2003 - academic.oup.com
Aims Clopidogrel is a pro-drug which is converted to an active, unstable drug by cytochrome
P450 (CYP). The active drug irreversibly blocks one specific platelet adenosine 5 …

Differential regulation of endothelial cell adhesion molecule expression by nitric oxide donors and antioxidants

M Spiecker, H Darius, K Kaboth… - Journal of leukocyte …, 1998 - academic.oup.com
Although nitric oxide (NO) and antioxidants inhibit adhesion molecule expression, their
inhibitory effects on nuclear factor κB (NF-κB) activation may differ. The NO donors, but not 8 …

Granular aluminium as a superconducting material for high-impedance quantum circuits

L Grünhaupt, M Spiecker, D Gusenkova, N Maleeva… - Nature materials, 2019 - nature.com
Superconducting quantum information processing machines are predominantly based on
microwave circuits with relatively low characteristic impedance, about 100 Ω, and small …

Two-level system hyperpolarization using a quantum Szilard engine

M Spiecker, P Paluch, N Gosling, N Drucker… - Nature Physics, 2023 - nature.com
The innate complexity of solid-state physics exposes superconducting quantum circuits to
interactions with uncontrolled degrees of freedom degrading their coherence. By …

Cloning of CYP2J2 gene and identification of functional polymorphisms

…, J Graves, JA Bradbury, L Li, M Spiecker… - Molecular …, 2002 - ASPET
CYP2J2 is abundant in cardiovascular tissue and active in the metabolism of arachidonic
acid to eicosanoids that possess potent anti-inflammatory, vasodilatory, and fibrinolytic …