Maturation of heart valve cell populations during postnatal remodeling

A Hulin, L Hortells, MV Gomez-Stallons… - …, 2019 - journals.biologists.com
Heart valve cells mediate extracellular matrix (ECM) remodeling during postnatal valve
leaflet stratification, but phenotypic and transcriptional diversity of valve cells in development …

Bone morphogenetic protein signaling is required for aortic valve calcification

MV Gomez-Stallons… - … , and vascular biology, 2016 - Am Heart Assoc
Objective—Calcific aortic valve disease (CAVD) is the most prevalent type of heart valve
disease, affecting≈ 2% of the US population. CAVD is characterized by the presence of …

Calcification and extracellular matrix dysregulation in human postmortem and surgical aortic valves

MV Gomez-Stallons, JT Tretter, K Hassel… - Heart, 2019 - heart.bmj.com
Objectives Calcific aortic valve disease (CAVD) is a progressive disease ranging from aortic
valve (AoV) sclerosis to AoV stenosis (AS), characterised by severe calcification with …

[PDF][PDF] Molecular mechanisms of heart valve development and disease

MV Gomez Stallons… - … of Congenital Heart …, 2016 - library.oapen.org
The mature heart valves consist of stratified extracellular matrix (ECM) layers, and heart
valve disease is characterized by ECM dysregulation and mineralization. There is …

Developmental pathways and aortic valve calcification

MV Gomez-Stallons, K Hassel, KE Yutzey - … Calcification and Bone …, 2020 - Springer
Calcific aortic valve disease (CAVD) has been associated with activation of molecular
pathways involved in both heart valve and bone development. There is increasing evidence …

[CITATION][C] BMP signaling is required for aortic valve calcification HHS public access

MV Gomez-Stallons, EE Wirrig-Schwendeman… - Arter. Thromb Vasc Biol, 2016