The impetus for developing methods for the construction of seven-membered rings derives
from the common occurrence of these frameworks in biologically active natural products. It is …

Conformationally constrained amino acids (AAs) have been the focus of both synthetic and
medicinal chemistry, particularly as they apply to the design of novel peptides. 1 Rigidified …

There has been a plethora of polymer-supported syntheses since Merrifield1 began peptide
synthesis on the solid phase. Solid-phase organic synthesis (SPOS) has become a very …

Mitochondrial fusion and division play important roles in the regulation of apoptosis.
Mitochondrial fusion proteins attenuate apoptosis by inhibiting release of cytochrome c from …

Infectious and environmental agents have been proposed as immunologic triggers for
primary biliary cirrhosis (PBC). Recently, a ubiquitous organism that metabolizes organic …

The flavonoid genistein and the benzo [c] quinolizinium MPB-07 have been shown to
activate the cystic fibrosis transmembrane conductance regulator (CFTR), the protein that is …

Emerging evidence has suggested environmental factors as causative agents in the
pathogenesis of primary biliary cirrhosis (PBC). We have hypothesized that in PBC the lipoyl …

There have been important advances in defining effector mechanisms for several human
autoimmune diseases. However, for most human autoimmune diseases, the induction stage …

Antimitochondrial antibodies (AMA) are unique among autoimmune serologic reactants
because of their extremely high association with the index disease primary biliary cirrhosis …

Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) chloride
channel cause cystic fibrosis. The ΔF508 mutation produces defects in channel gating and …