Inherited thoracic aortic disease: new insights and translational targets

AJ Fletcher, MBJ Syed, TJ Aitman, DE Newby… - Circulation, 2020 - Am Heart Assoc
Inherited thoracic aortopathies denote a group of congenital conditions that predispose to
disease of the thoracic aorta. Aortic wall weakness and abnormal aortic hemodynamic …

Emerging techniques in atherosclerosis imaging

MBJ Syed, AJ Fletcher, RO Forsythe… - The British Journal of …, 2019 - academic.oup.com
Atherosclerosis is a chronic immunomodulated disease that affects multiple vascular beds
and results in a significant worldwide disease burden. Conventional imaging modalities …

Effect of denosumab or alendronic acid on the progression of aortic stenosis: a double-blind randomized controlled trial

TA Pawade, MK Doris, R Bing, AC White, L Forsyth… - Circulation, 2021 - Am Heart Assoc
Background: Valvular calcification is central to the pathogenesis and progression of aortic
stenosis, with preclinical and observational studies suggesting that bone turnover and …

Coronary 18F-Fluoride Uptake and Progression of Coronary Artery Calcification

MK Doris, MN Meah, AJ Moss… - Circulation …, 2020 - Am Heart Assoc
Background Positron emission tomography (PET) using 18F-sodium fluoride (18F-fluoride)
to detect microcalcification may provide insight into disease activity in coronary …

Immune dysfunction and risk of infection in chronic kidney disease

M Syed-Ahmed, M Narayanan - Advances in chronic kidney disease, 2019 - Elsevier
Cardiovascular disease and infections are directly or indirectly associated with an altered
immune response, which leads to a high incidence of morbidity and mortality, and together …

Thoracic Aortic 18F-Sodium Fluoride Activity and Ischemic Stroke in Patients With Established Cardiovascular Disease

AJ Fletcher, YY Tew, E Tzolos, SS Joshi… - Cardiovascular …, 2022 - jacc.org
Background Aortic atherosclerosis represents an important contributor to ischemic stroke
risk. Identifying patients with high-risk aortic atheroma could improve preventative treatment …

[HTML][HTML] Biomechanical assessment predicts aneurysm related events in patients with abdominal aortic aneurysm

BJ Doyle, N Bappoo, MBJ Syed, RO Forsythe… - European Journal of …, 2020 - Elsevier
Objective To test whether aneurysm biomechanical ratio (ABR; a dimensionless ratio of wall
stress and wall strength) can predict aneurysm related events. Methods In a prospective …

18F-NaF PET/MRI for Detection of Carotid Atheroma in Acute Neurovascular Syndrome

J Kaczynski, S Sellers, MA Seidman, M Syed, M Dennis… - Radiology, 2022 - pubs.rsna.org
Background MRI and fluorine 18–labeled sodium fluoride (18F-NaF) PET can be used to
identify features of plaque instability, rupture, and disease activity, but large studies have not …

Quantifying microcalcification activity in the thoracic aorta

AJ Fletcher, M Lembo, J Kwiecinski, MBJ Syed… - Journal of Nuclear …, 2022 - Elsevier
Background Standard methods for quantifying positron emission tomography (PET) uptake
in the aorta are time consuming and may not reflect overall vessel activity. We describe …

Low shear stress at baseline predicts expansion and aneurysm-related events in patients with abdominal aortic aneurysm

N Bappoo, MBJ Syed, G Khinsoe… - Circulation …, 2021 - Am Heart Assoc
Background: Low shear stress has been implicated in abdominal aortic aneurysm (AAA)
expansion and clinical events. We tested the hypothesis that low shear stress in AAA at …