In people suffering from schizophrenia, major areas of everyday life are impaired, including
independent living, productive activities and social relationships. Enhanced understanding …

DNA methylation at CpG dinucleotides is associated with gene silencing, stress, and
memory. The catechol-O-methyltransferase (COMT) Val158 allele in rs4680 is associated …

Self-reported 'personal recovery'and clinical recovery in schizophrenia (SRPR and CR,
respectively) reflect different perspectives in schizophrenia outcome, not necessarily …

Leptin is a pleiotropic molecule involved in energy homeostasis, hematopoiesis,
inflammation, and immunity. Hypoleptinemia characterizing starvation has been strictly …

Dopamine D2 and serotonin 5-HT2A receptors contribute to modulate prefrontal cortical
physiology and response to treatment with antipsychotics in schizophrenia. Similarly …

Epigenetic mechanisms can mediate gene-environment interactions relevant for complex
disorders. The BDNF gene is crucial for development and brain plasticity, is sensitive to …

The default mode network (DMN) comprises a set of brain regions with “increased” activity
during rest relative to cognitive processing. Activity in the DMN is associated with functional …

Neutrophil apoptosis represents a crucial step in the mechanisms governing the resolution
of neutrophilic inflammation. Several soluble mediators of inflammation modulate neutrophil …

Objective Glycogen synthase kinase 3β (GSK-3β) is an enzyme implicated in
neurodevelopmental processes with a broad range of substrates mediating several …

Background Pill-in-the-pocket treatment should be prescribed only if the administration of a
loading oral dose of flecainide or propafenone has been proved safe in hospital, since major …