Neural tube closure takes place during early embryogenesis and requires interactions
between genetic and environmental factors. Failure of neural tube closure is a common …

Previous studies have shown an increased risk of retinal vein occlusion (RVO) in patients
with hypertension, hypercholesterolemia and diabetes mellitus. Literature on the association …

Elevated plasma homocysteine concentration has been suggested as a risk factor for
schizophrenia, but the results of epidemiological studies have been inconsistent. The most …

Smoking is a common risk factor for many diseases. We conducted genome-wide
association meta-analyses for the number of cigarettes smoked per day (CPD) in smokers …

Background Previous studies have suggested that hyperhomocysteinemia may be a risk
factor for venous thrombosis. To assess the risk of venous thrombosis associated with …

Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain
largely elusive. To identify genetic loci for obesity susceptibility, we examined associations …

Approaches exploiting trait distribution extremes may be used to identify loci associated with
common traits, but it is unknown whether these loci are generalizable to the broader …

Mild hyperhomocysteinemia is an established risk factor for cardiovascular disease. Genetic
aberrations in the cystathionine beta-synthase (CBS) and methylenetetrahydrofolate …

Given the anthropometric differences between men and women and previous evidence of
sex-difference in genetic effects, we conducted a genome-wide search for sexually …

Background Idiopathic membranous nephropathy is a major cause of the nephrotic
syndrome in adults, but its etiologic basis is not fully understood. We investigated the genetic …