Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants
Background and Purpose—Ischemic stroke (IS) and coronary artery disease (CAD) share
several risk factors and each has a substantial heritability. We conducted a genome-wide …
several risk factors and each has a substantial heritability. We conducted a genome-wide …
[HTML][HTML] MicroRNAs in cardiovascular disease: an introduction for clinicians
SPR Romaine, M Tomaszewski, G Condorelli… - Heart, 2015 - heart.bmj.com
MicroRNAs (miRNAs) are small, non-coding, RNA molecules approximately 22 nucleotides
in length which act as post-transcriptional regulators of gene expression. Individual miRNAs …
in length which act as post-transcriptional regulators of gene expression. Individual miRNAs …
Mendelian randomization studies in coronary artery disease
H Jansen, NJ Samani, H Schunkert - European heart journal, 2014 - academic.oup.com
Epidemiological research over the last 50 years has discovered a plethora of biomarkers
(including molecules, traits or other diseases) that associate with coronary artery disease …
(including molecules, traits or other diseases) that associate with coronary artery disease …
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants
Heart Attack Risk in Puget Sound. Schwartz Stephen … - Nature …, 2009 - nature.com
We conducted a genome-wide association study testing single nucleotide polymorphisms
(SNPs) and copy number variants (CNVs) for association with early-onset myocardial …
(SNPs) and copy number variants (CNVs) for association with early-onset myocardial …
Common variants near MC4R are associated with fat mass, weight and risk of obesity
To identify common variants influencing body mass index (BMI), we analyzed genome-wide
association data from 16,876 individuals of European descent. After previously reported …
association data from 16,876 individuals of European descent. After previously reported …
[HTML][HTML] Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study
Background High plasma HDL cholesterol is associated with reduced risk of myocardial
infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes …
infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes …
Genome-wide association study identifies eight loci associated with blood pressure
Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide.
To date, identification of common genetic variants influencing blood pressure has proven …
To date, identification of common genetic variants influencing blood pressure has proven …
[HTML][HTML] Genomewide association analysis of coronary artery disease
Background Modern genotyping platforms permit a systematic search for inherited
components of complex diseases. We performed a joint analysis of two genomewide …
components of complex diseases. We performed a joint analysis of two genomewide …
Identification of seven loci affecting mean telomere length and their association with disease
Interindividual variation in mean leukocyte telomere length (LTL) is associated with cancer
and several age-associated diseases. We report here a genome-wide meta-analysis of …
and several age-associated diseases. We report here a genome-wide meta-analysis of …
Human metabolic individuality in biomedical and pharmaceutical research
Genome-wide association studies (GWAS) have identified many risk loci for complex
diseases, but effect sizes are typically small and information on the underlying biological …
diseases, but effect sizes are typically small and information on the underlying biological …