The mechanisms by which physical forces regulate endothelial cells to determine the
complexities of vascular structure and function are enigmatic,,,,. Studies of sensory neurons …

We have identified a Y-chromosomal lineage with several unusual features. It was found in
16 populations throughout a large region of Asia, stretching from the Pacific to the Caspian …

The nonrecombining portion of the human Y chromosome has proven to be a valuable tool
for the study of population history. The maintenance of extended haplotypes characteristic of …

Mammalian biology adapts to physical activity but the molecular mechanisms sensing the
activity remain enigmatic. Recent studies have revealed how Piezo1 protein senses …

Endothelial cell (EC) metabolism is emerging as a regulator of angiogenesis, but the precise
role of glutamine metabolism in EC s is unknown. Here, we show that depriving EC s of …

Sixteen Y-chromosomal microsatellites and 16 binary markers have been used to analyze
DNA variation in 408 male subjects from 15 populations in Central Asia. Large genetic …

Oxidized low-density lipoprotein (oxLDL) promotes unregulated platelet activation in
dyslipidemic disorders. Although oxLDL stimulates activatory signaling, it is unclear how …

Rationale: Transient receptor potential melastatin (TRPM) 3 is a calcium-permeable ion
channel activated by the neurosteroid pregnenolone sulfate and positively coupled to insulin …

Insulin resistance is characterized by excessive endothelial cell generation of potentially
cytotoxic concentrations of reactive oxygen species. We examined the role of NADPH …

Low concentrations of insulin-like growth factor (IGF) binding protein-1 (IGFBP1) are
associated with insulin resistance, diabetes, and cardiovascular disease. We investigated …