POPDC2 a novel susceptibility gene for conduction disorders

S Rinné, B Ortiz-Bonnin, B Stallmeyer, AK Kiper… - Journal of Molecular and …, 2020 - Elsevier
Despite recent progress in the understanding of cardiac ion channel function and its role in
inherited forms of ventricular arrhythmias, the molecular basis of cardiac conduction …

[HTML][HTML] Cardiac optical mapping–State-of-the-art and future challenges

C O'Shea, SN Kabir, AP Holmes, M Lei, L Fabritz… - The international journal …, 2020 - Elsevier
Cardiac optical mapping utilises fluorescent dyes to directly image the electrical function of
the heart at a high spatio-temporal resolution which far exceeds electrode techniques. It has …

[HTML][HTML] Reduced left atrial cardiomyocyte PITX2 and elevated circulating BMP10 predict atrial fibrillation after ablation

JS Reyat, W Chua, VR Cardoso, A Witten, PM Kastner… - JCI insight, 2020 - ncbi.nlm.nih.gov
BACKGROUND Genomic and experimental studies suggest a role for PITX2 in atrial
fibrillation (AF). To assess if this association is relevant for recurrent AF in patients, we tested …

Diminished PLK2 induces cardiac fibrosis and promotes atrial fibrillation

SR Künzel, M Hoffmann, S Weber, K Künzel… - Circulation …, 2021 - Am Heart Assoc
Rationale: Fibrosis promotes the maintenance of atrial fibrillation (AF), making it resistant to
therapy. Improved understanding of the molecular mechanisms leading to atrial fibrosis will …

[HTML][HTML] High resolution optical mapping of cardiac electrophysiology in pre-clinical models

C O'Shea, J Winter, SN Kabir, M O'Reilly, SP Wells… - Scientific Data, 2022 - nature.com
Optical mapping of animal models is a widely used technique in pre-clinical cardiac
research. It has several advantages over other methods, including higher spatial resolution …

[HTML][HTML] Increased atrial effectiveness of flecainide conferred by altered biophysical properties of sodium channels

S O'Brien, AP Holmes, DM Johnson, SN Kabir… - Journal of Molecular and …, 2022 - Elsevier
Atrial fibrillation (AF) affects over 1% of the population and is a leading cause of stroke and
heart failure in the elderly. A feared side effect of sodium channel blocker therapy …

[HTML][HTML] Atrial resting membrane potential confers sodium current sensitivity to propafenone, flecainide and dronedarone

AP Holmes, P Saxena, SN Kabir, C O'Shea… - Heart Rhythm, 2021 - Elsevier
Background Although atrial fibrillation ablation is increasingly used for rhythm control
therapy, antiarrhythmic drugs (AADs) are commonly used, either alone or in combination …

Effects of genetic background, sex, and age on murine atrial electrophysiology

J Obergassel, M O'Reilly, LC Sommerfeld… - EP …, 2021 - academic.oup.com
Aims Genetically altered mice are powerful models to investigate mechanisms of atrial
arrhythmias, but normal ranges for murine atrial electrophysiology have not been robustly …

Reduced plakoglobin increases the risk of sodium current defects and atrial conduction abnormalities in response to androgenic anabolic steroid abuse

LC Sommerfeld, AP Holmes, TY Yu… - The Journal of …, 2024 - Wiley Online Library
Androgenic anabolic steroids (AAS) are commonly abused by young men. Male sex and
increased AAS levels are associated with earlier and more severe manifestation of common …

Male sex hormone and reduced plakoglobin jointly impair atrial conduction and cardiac sodium currents

LC Sommerfeld, AP Holmes, TY Yu, C O'Shea… - bioRxiv, 2022 - biorxiv.org
Androgenic anabolic steroids (AAS) are commonly abused by young men. Male sex
associates with earlier manifestation of common and rare cardiac conditions including atrial …