POPDC2 a novel susceptibility gene for conduction disorders
S Rinné, B Ortiz-Bonnin, B Stallmeyer, AK Kiper… - Journal of Molecular and …, 2020 - Elsevier
Despite recent progress in the understanding of cardiac ion channel function and its role in
inherited forms of ventricular arrhythmias, the molecular basis of cardiac conduction …
inherited forms of ventricular arrhythmias, the molecular basis of cardiac conduction …
[HTML][HTML] Cardiac optical mapping–State-of-the-art and future challenges
Cardiac optical mapping utilises fluorescent dyes to directly image the electrical function of
the heart at a high spatio-temporal resolution which far exceeds electrode techniques. It has …
the heart at a high spatio-temporal resolution which far exceeds electrode techniques. It has …
[HTML][HTML] Reduced left atrial cardiomyocyte PITX2 and elevated circulating BMP10 predict atrial fibrillation after ablation
JS Reyat, W Chua, VR Cardoso, A Witten, PM Kastner… - JCI insight, 2020 - ncbi.nlm.nih.gov
BACKGROUND Genomic and experimental studies suggest a role for PITX2 in atrial
fibrillation (AF). To assess if this association is relevant for recurrent AF in patients, we tested …
fibrillation (AF). To assess if this association is relevant for recurrent AF in patients, we tested …
Diminished PLK2 induces cardiac fibrosis and promotes atrial fibrillation
SR Künzel, M Hoffmann, S Weber, K Künzel… - Circulation …, 2021 - Am Heart Assoc
Rationale: Fibrosis promotes the maintenance of atrial fibrillation (AF), making it resistant to
therapy. Improved understanding of the molecular mechanisms leading to atrial fibrosis will …
therapy. Improved understanding of the molecular mechanisms leading to atrial fibrosis will …
[HTML][HTML] High resolution optical mapping of cardiac electrophysiology in pre-clinical models
C O'Shea, J Winter, SN Kabir, M O'Reilly, SP Wells… - Scientific Data, 2022 - nature.com
Optical mapping of animal models is a widely used technique in pre-clinical cardiac
research. It has several advantages over other methods, including higher spatial resolution …
research. It has several advantages over other methods, including higher spatial resolution …
[HTML][HTML] Increased atrial effectiveness of flecainide conferred by altered biophysical properties of sodium channels
S O'Brien, AP Holmes, DM Johnson, SN Kabir… - Journal of Molecular and …, 2022 - Elsevier
Atrial fibrillation (AF) affects over 1% of the population and is a leading cause of stroke and
heart failure in the elderly. A feared side effect of sodium channel blocker therapy …
heart failure in the elderly. A feared side effect of sodium channel blocker therapy …
[HTML][HTML] Atrial resting membrane potential confers sodium current sensitivity to propafenone, flecainide and dronedarone
Background Although atrial fibrillation ablation is increasingly used for rhythm control
therapy, antiarrhythmic drugs (AADs) are commonly used, either alone or in combination …
therapy, antiarrhythmic drugs (AADs) are commonly used, either alone or in combination …
Effects of genetic background, sex, and age on murine atrial electrophysiology
J Obergassel, M O'Reilly, LC Sommerfeld… - EP …, 2021 - academic.oup.com
Aims Genetically altered mice are powerful models to investigate mechanisms of atrial
arrhythmias, but normal ranges for murine atrial electrophysiology have not been robustly …
arrhythmias, but normal ranges for murine atrial electrophysiology have not been robustly …
Reduced plakoglobin increases the risk of sodium current defects and atrial conduction abnormalities in response to androgenic anabolic steroid abuse
LC Sommerfeld, AP Holmes, TY Yu… - The Journal of …, 2024 - Wiley Online Library
Androgenic anabolic steroids (AAS) are commonly abused by young men. Male sex and
increased AAS levels are associated with earlier and more severe manifestation of common …
increased AAS levels are associated with earlier and more severe manifestation of common …
Male sex hormone and reduced plakoglobin jointly impair atrial conduction and cardiac sodium currents
LC Sommerfeld, AP Holmes, TY Yu, C O'Shea… - bioRxiv, 2022 - biorxiv.org
Androgenic anabolic steroids (AAS) are commonly abused by young men. Male sex
associates with earlier manifestation of common and rare cardiac conditions including atrial …
associates with earlier manifestation of common and rare cardiac conditions including atrial …