Epoxyeicosatrienoic acids (EETs), which are synthesized from arachidonic acid by
cytochrome P450 epoxygenases, function primarily as autocrine and paracrine effectors in …

The role of inflammation in the pathogenesis of abdominal aortic aneurysms (AAA) is well
established. The inflammatory process leads to protease-mediated degradation of the …

Atherosclerosis is increasingly recognized as a chronic inflammatory disease. Although a
variety of inflammatory markers (ie, C-reactive protein) have been associated with …

Background—Ghrelin is a novel growth hormone-releasing peptide that has been shown to
improve cachexia in heart failure and cancer and to ameliorate the hemodynamic and …

Adipose tissue depots originate from distinct precursor cells, are functionally diverse, and
modulate disease processes in a depot-specific manner. However, the functional properties …

Background/objectives Induced pluripotent stem cells (iPS) exhibit enhanced survival and
proliferation in ischemic tissues. However, the therapeutic application of iPS cells is limited …

Abdominal aortic aneurysm (AAA) is an inflammatory disorder characterized by localized
connective tissue degradation and smooth muscle cell (SMC) apoptosis, leading to aortic …

Non-phagocytic NAD (P) H oxidases have been implicated as major sources of reactive
oxygen species in blood vessels. These oxidases can be activated by cytokines, thereby …

With a prevalence of 5 800 000 (2% of the entire populace) in 2009 and an estimated yearly
incidence of 550 000, the burden of heart failure (HF) in the United States is tremendous. 1 …

Cytochrome P450 epoxygenases convert arachidonic acid into 4 epoxyeicosatrienoic acid
(EET) regioisomers, which were recently identified as endothelium-derived hyperpolarizing …