Abstract Changes in chromatin structure underlie the activation or silencing of genes during
development. The chromatin remodeler Mi-2β is highly expressed in thymocytes and is …

Rationale: The Notch signaling pathway is crucial for primitive cardiac valve formation by
epithelial–mesenchymal transition, and NOTCH1 mutations cause bicuspid aortic valve; …

Ikaros is a key regulator of lymphocyte proliferative responses. Inactivating mutations in
Ikaros cause antigen-mediated lymphocyte hyperproliferation and the rapid development of …

Ikaros plays a key role in lymphocyte development and homeostasis by both potentiating
and repressing gene expression. Here we show that Ikaros interacts with components of the …

Loss of the transcription factor Ikaros is correlated with Notch receptor activation in T cell
acute lymphoblastic leukemia (T-ALL). However, the mechanism remains unknown. We …

Heart muscle maintains blood circulation, while skeletal muscle powers skeletal movement.
Despite having similar myofibrilar sarcomeric structures, these striated muscles differentially …

Lineage commitment is induced by changes in gene expression dictated by the intimate
interaction between transcription factors and chromatin regulators. Here, we revealed the …

Although important advances have been made in the development of antibiotics and
medical intensive care technology in recent years, systemic response to infection remains a …

Objective—Vascular endothelial growth factor (VEGF) has been identified as a crucial
regulator of physiological and pathological angiogenesis. Among the intracellular signaling …

Chromodomain-helicase-DNA-binding protein 4 (CHD4) is an epigenetic regulator identified
as an oncogenic element that may provide a novel therapeutic target for the treatment of …