Objective. To examine the influence of initial infant feeding on obesity in later life. Methods.
A systematic review of published studies investigating the association between infant …

Context Low birth weight is implicated as a risk factor for type 2 diabetes. However, the
strength, consistency, independence, and shape of the association have not been …

Objective To examine the dose-response associations between accelerometer assessed
total physical activity, different intensities of physical activity, and sedentary time and all …

Objective: To assess associations between baseline values of four different circulating
markers of inflammation and future risk of coronary heart disease, potential triggers of …

The contribution of rare and low-frequency variants to human traits is largely unexplored.
Here we describe insights from sequencing whole genomes (low read depth, 7×) or exomes …

Background Although 10 000 steps per day is widely promoted to have health benefits, there
is little evidence to support this recommendation. We aimed to determine the association …

Objective To establish the predictive accuracy of the Framingham risk score for coronary
heart disease in a representative British population. Design Prospective cohort study …

Background and Purpose—B-mode ultrasound is a noninvasive method of examining the
walls of peripheral arteries and provides measures of the intima-media thickness (IMT) at …

Background Statins increase the risk of new-onset type 2 diabetes mellitus. We aimed to
assess whether this increase in risk is a consequence of inhibition of 3-hydroxy-3 …

Background The relevance to coronary heart disease (CHD) of cytokines that govern
inflammatory cascades, such as interleukin-6 (IL-6), may be underestimated because such …