User profiles for "author:Philip Hawkins"
Philip HawkinsProfessor of Medicine Verified email at ucl.ac.uk Cited by 65062 |
Definition of organ involvement and treatment response in immunoglobulin light chain amyloidosis (AL): A consensus opinion from the 10th International Symposium …
MA Gertz, R Comenzo, RH Falk… - American journal of …, 2005 - Wiley Online Library
We undertook this study to develop uniformly accepted criteria for the definition of organ
involvement and response for patients on treatment protocols for immunoglobulin light …
involvement and response for patients on treatment protocols for immunoglobulin light …
Systemic amyloidosis
Tissue deposition of protein fibrils causes a group of rare diseases called systemic
amyloidoses. This Seminar focuses on changes in their epidemiology, the current approach …
amyloidoses. This Seminar focuses on changes in their epidemiology, the current approach …
Systemic immunoglobulin light chain amyloidosis
G Merlini, A Dispenzieri, V Sanchorawala… - Nature reviews Disease …, 2018 - nature.com
Systemic immunoglobulin light chain amyloidosis is a protein misfolding disease caused by
the conversion of immunoglobulin light chains from their soluble functional states into highly …
the conversion of immunoglobulin light chains from their soluble functional states into highly …
[HTML][HTML] Patisiran, an RNAi therapeutic, for hereditary transthyretin amyloidosis
D Adams, A Gonzalez-Duarte… - New england journal …, 2018 - Mass Medical Soc
Background Patisiran, an investigational RNA interference therapeutic agent, specifically
inhibits hepatic synthesis of transthyretin. Methods In this phase 3 trial, we randomly …
inhibits hepatic synthesis of transthyretin. Methods In this phase 3 trial, we randomly …
[PDF][PDF] NALP3 forms an IL-1β-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder
L Agostini, F Martinon, K Burns, MF McDermott… - Immunity, 2004 - cell.com
Mutations within the NALP3/cryopyrin/CIAS1 gene are responsible for three
autoinflammatory disorders: Muckle-Wells syndrome, familial cold autoinflammatory …
autoinflammatory disorders: Muckle-Wells syndrome, familial cold autoinflammatory …
Nonbiopsy diagnosis of cardiac transthyretin amyloidosis
Background—Cardiac transthyretin (ATTR) amyloidosis is a progressive and fatal
cardiomyopathy for which several promising therapies are in development. The diagnosis is …
cardiomyopathy for which several promising therapies are in development. The diagnosis is …
[PDF][PDF] Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine
EH Walker, ME Pacold, O Perisic, L Stephens… - Molecular cell, 2000 - cell.com
The specific phosphoinositide 3-kinase (PI3K) inhibitors wortmannin and LY294002 have
been invaluable tools for elucidating the roles of these enzymes in signal transduction …
been invaluable tools for elucidating the roles of these enzymes in signal transduction …
Cardiovascular magnetic resonance in cardiac amyloidosis
AM Maceira, J Joshi, SK Prasad, JC Moon, E Perugini… - Circulation, 2005 - Am Heart Assoc
Background—Cardiac amyloidosis can be diagnostically challenging. Cardiovascular
magnetic resonance (CMR) can assess abnormal myocardial interstitium. Methods and …
magnetic resonance (CMR) can assess abnormal myocardial interstitium. Methods and …
Instability, unfolding and aggregation of human lysozyme variants underlying amyloid fibrillogenesis
Tissue deposition of soluble proteins as amyloid fibrils underlies a range of fatal diseases.
The two naturally occurring human lysozyme variants are both amyloidogenic, and are …
The two naturally occurring human lysozyme variants are both amyloidogenic, and are …
[HTML][HTML] Natural history and outcome in systemic AA amyloidosis
HJ Lachmann, HJB Goodman… - … England Journal of …, 2007 - Mass Medical Soc
Background Deposition of amyloid fibrils derived from circulating acute-phase reactant
serum amyloid A protein (SAA) causes systemic AA amyloidosis, a serious complication of …
serum amyloid A protein (SAA) causes systemic AA amyloidosis, a serious complication of …