[HTML][HTML] NOTCH1 signaling in head and neck squamous cell carcinoma
Biomarker-driven targeted therapies are lacking for head and neck squamous cell
carcinoma (HNSCC), which is common and lethal. Efforts to develop such therapies are …
carcinoma (HNSCC), which is common and lethal. Efforts to develop such therapies are …
[HTML][HTML] Effectiveness and cost-effectiveness of mindfulness-based cognitive therapy compared with maintenance antidepressant treatment in the prevention of …
Background Individuals with a history of recurrent depression have a high risk of repeated
depressive relapse or recurrence. Maintenance antidepressants for at least 2 years is the …
depressive relapse or recurrence. Maintenance antidepressants for at least 2 years is the …
[HTML][HTML] Novel systemic treatment modalities including immunotherapy and molecular targeted therapy for recurrent and metastatic head and neck squamous cell …
Head and neck squamous cell carcinomas (HNSCCs) are the sixth most common cancers
worldwide. More than half of patients with HNSCC eventually experience disease …
worldwide. More than half of patients with HNSCC eventually experience disease …
[HTML][HTML] Birth-related perineal trauma in low-and middle-income countries: a systematic review and meta-analysis
Introduction Birth-related perineal trauma (BPT) is a common consequence of vaginal births.
When poorly managed, BPT can result in increased morbidity and mortality due to infections …
When poorly managed, BPT can result in increased morbidity and mortality due to infections …
Patient-nurse interrater reliability and agreement of the Richards-Campbell sleep questionnaire
Background The Richards-Campbell Sleep Questionnaire (RCSQ) is a simple, validated
survey instrument for measuring sleep quality in intensive care patients. Although both …
survey instrument for measuring sleep quality in intensive care patients. Although both …
Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitor
X He, J Riceberg, T Soucy, E Koenig… - Nature chemical …, 2017 - nature.com
Small ubiquitin-like modifier (SUMO) family proteins regulate target-protein functions by post-
translational modification. However, a potent and selective inhibitor targeting the SUMO …
translational modification. However, a potent and selective inhibitor targeting the SUMO …
[PDF][PDF] Comparative study of DPPH, ABTS and FRAP assays for determination of antioxidant activity
P Shah, HA Modi - Int. J. Res. Appl. Sci. Eng. Technol, 2015 - researchgate.net
Three simple spectrophotometric methods:(1, 1-diphenyl-2-picrylhydrazyl) free radical
scavenging activity assay (DPPH),[2, 2'-azinobis (3-ethylbenzothiazoline-6-sulphonic acid)] …
scavenging activity assay (DPPH),[2, 2'-azinobis (3-ethylbenzothiazoline-6-sulphonic acid)] …
A small-molecule SUMOylation inhibitor activates antitumor immune responses and potentiates immune therapies in preclinical models
ES Lightcap, P Yu, S Grossman, K Song… - Science translational …, 2021 - science.org
SUMOylation, the covalent conjugation of small ubiquitin-like modifier (SUMO) proteins to
protein substrates, has been reported to suppress type I interferon (IFN1) responses. TAK …
protein substrates, has been reported to suppress type I interferon (IFN1) responses. TAK …
SMAD4 suppresses WNT-driven dedifferentiation and oncogenesis in the differentiated gut epithelium
The cell of origin of colon cancer is typically thought to be the resident somatic stem cells,
which are immortal and escape the continual cellular turnover characteristic of the intestinal …
which are immortal and escape the continual cellular turnover characteristic of the intestinal …
[HTML][HTML] Characterization of the loss of SUMO pathway function on cancer cells and tumor proliferation
X He, J Riceberg, SM Pulukuri, S Grossman, V Shinde… - PloS one, 2015 - journals.plos.org
SUMOylation is a post-translational ubiquitin-like protein modification pathway that regulates
important cellular processes including chromosome structure, kinetochore function …
important cellular processes including chromosome structure, kinetochore function …