[HTML][HTML] Endothelial depletion of Acvrl1 in mice leads to arteriovenous malformations associated with reduced endoglin expression

S Tual-Chalot, M Mahmoud, KR Allinson… - PloS one, 2014 - journals.plos.org
Rare inherited cardiovascular diseases are frequently caused by mutations in genes that are
essential for the formation and/or function of the cardiovasculature. Hereditary …

Heart disease and ageing: the roles of senescence, mitochondria, and telomerase in cardiovascular disease

LK Booth, RE Redgrave, S Tual-Chalot… - Biochemistry and Cell …, 2023 - Springer
During ageing molecular damage leads to the accumulation of several hallmarks of ageing
including mitochondrial dysfunction, cellular senescence, genetic instability and chronic …

Role of soluble endoglin in BMP9 signaling

A Lawera, Z Tong, M Thorikay… - Proceedings of the …, 2019 - National Acad Sciences
Endoglin (ENG) is a coreceptor of the transforming growth factor-β (TGFβ) family signaling
complex, which is highly expressed on endothelial cells and plays a key role in …

[HTML][HTML] Senescent cardiomyocytes contribute to cardiac dysfunction following myocardial infarction

RE Redgrave, E Dookun, LK Booth… - npj Aging, 2023 - nature.com
Myocardial infarction is a leading cause of morbidity and mortality. While reperfusion is now
standard therapy, pathological remodelling leading to heart failure remains a clinical …

Loss of endothelial endoglin promotes high-output heart failure through peripheral arteriovenous shunting driven by VEGF signaling

S Tual-Chalot, M Garcia-Collado… - Circulation …, 2020 - Am Heart Assoc
Rationale: ENG (endoglin) is a coreceptor for BMP (bone morphogenetic protein) 9/10 and
is strongly expressed in endothelial cells. Mutations in ENG lead to the inherited vascular …

[HTML][HTML] Arterial endoglin does not protect against arteriovenous malformations

E Singh, RE Redgrave, HM Phillips, HM Arthur - Angiogenesis, 2020 - Springer
Introduction Endoglin (ENG) forms a receptor complex with ALK1 in endothelial cells (ECs)
to promote BMP9/10 signalling. Loss of function mutations in either ENG or ALK1 genes …

[PDF][PDF] Cardiosphere-derived cells require endoglin for paracrine-mediated angiogenesis

RE Redgrave, S Tual-Chalot, BJ Davison, E Singh… - Stem cell reports, 2017 - cell.com
Clinical trials of stem cell therapy to treat ischemic heart disease primarily use
heterogeneous stem cell populations. Small benefits occur via paracrine mechanisms that …

[HTML][HTML] Anthracycline-induced cardiotoxicity and senescence

LK Booth, RE Redgrave, O Folaranmi, JH Gill… - Frontiers in …, 2022 - frontiersin.org
Cancer continues to place a heavy burden on healthcare systems around the world.
Although cancer survivorship continues to improve, cardiotoxicity leading to cardiomyopathy …

[HTML][HTML] MiR-126-3p is dynamically regulated in endothelial-to-mesenchymal transition during fibrosis

NP Jordan, SJ Tingle, VG Shuttleworth… - International Journal of …, 2021 - mdpi.com
In fibrotic diseases, myofibroblasts derive from a range of cell types including endothelial-to-
mesenchymal transition (EndMT). Increasing evidence suggests that miRNAs are key …

Cellular Senescence, Mitochondrial Dysfunction, and Their Link to Cardiovascular Disease

M Camacho-Encina, LK Booth, RE Redgrave… - Cells, 2024 - mdpi.com
Cardiovascular diseases (CVDs), a group of disorders affecting the heart or blood vessels,
are the primary cause of death worldwide, with an immense impact on patient quality of life …