Mitochondria are critical for sustaining life, not only as the essential powerhouses of cells but
as critical mediators of cell survival and death. Mitochondrial dysfunction has been identified …

The mechanism through which the protein kinase Akt (also called PKB), protects the heart
against acute ischaemia-reperfusion injury (IRI) is not clear. Here, we investigate whether …

T2-weighted cardiovascular magnetic resonance (T2-CMR) of myocardial edema can
quantify the area-at-risk (AAR) following acute myocardial infarction (AMI), and has been …

Background Novel therapeutic strategies are required to protect the myocardium against
ischaemia-reperfusion injury. Mitochondria are fundamental for the maintenance of cell …

In order to assess myocardial salvage when evaluating new therapeutic strategies for
myocardial infarction, we require the measurement of both infarct size and area-at-risk. In …

Background Cardiac-specific ablation of both Mfn1 and Mfn2 in the adult heart results in
mitochondrial fragmentation and a lethal cardiomyopathy after about 6 weeks. The effect of …

Background The mitochondrial specific deacetylase, Sirtuin-3 has been reported to regulate
oxidative phosphorylation, the activity of Cyclophilin D (a key component of the …