Antimalarial peroxides: advances in drug discovery and design
RD Slack, AM Jacobine, GH Posner - MedChemComm, 2012 - pubs.rsc.org
Cyclic peroxides such as the plant-derived 1, 2, 4-trioxane artemisinin and its derivatives are
short-lived, rapidly-acting antimalarials that are now usually combined with standard long …
short-lived, rapidly-acting antimalarials that are now usually combined with standard long …
Obesity paradox in a cohort of 4880 consecutive patients undergoing percutaneous coronary intervention
CE Hastie, S Padmanabhan, R Slack… - European heart …, 2010 - academic.oup.com
Aims We sought to investigate the impact of body mass index (BMI) on long-term all-cause
mortality in patients following first-time elective percutaneous coronary intervention (PCI) …
mortality in patients following first-time elective percutaneous coronary intervention (PCI) …
Previous coronary stent implantation and cardiac events in patients undergoing noncardiac surgery
NLM Cruden, SA Harding, AD Flapan… - Circulation …, 2010 - Am Heart Assoc
Background—Noncardiac surgery performed after coronary stent implantation is associated
with an increased risk of stent thrombosis, myocardial infarction, and death. The influence of …
with an increased risk of stent thrombosis, myocardial infarction, and death. The influence of …
Percutaneous coronary intervention in the elderly: changes in case-mix and periprocedural outcomes in 31 758 patients treated between 2000 and 2007
C Johnman, KG Oldroyd, DF Mackay… - Circulation …, 2010 - Am Heart Assoc
Background—The elderly account for an increasing proportion of the population and have a
high prevalence of coronary heart disease. Percutaneous coronary intervention (PCI) is the …
high prevalence of coronary heart disease. Percutaneous coronary intervention (PCI) is the …
Novel and high affinity 2-[(diphenylmethyl) sulfinyl] acetamide (modafinil) analogues as atypical dopamine transporter inhibitors
J Cao, RD Slack, OM Bakare, C Burzynski… - Journal of medicinal …, 2016 - ACS Publications
The development of pharmacotherapeutic treatments of psychostimulant abuse has
remained a challenge, despite significant efforts made toward relevant mechanistic targets …
remained a challenge, despite significant efforts made toward relevant mechanistic targets …
Using click chemistry toward novel 1, 2, 3-triazole-linked dopamine D3 receptor ligands
TM Keck, AK Banala, RD Slack, C Burzynski… - Bioorganic & medicinal …, 2015 - Elsevier
The dopamine D3 receptor (D3R) is a target of pharmacotherapeutic interest in a variety of
neurological disorders including schizophrenia, Parkinson's disease, restless leg syndrome …
neurological disorders including schizophrenia, Parkinson's disease, restless leg syndrome …
Clinical outcomes following radial versus femoral artery access in primary or rescue percutaneous coronary intervention in Scotland: retrospective cohort study of …
C Johnman, JP Pell, DF Mackay, M Behan, R Slack… - Heart, 2012 - heart.bmj.com
Objective To assess short-term and medium-term outcomes following radial and femoral
artery access for primary or rescue percutaneous coronary intervention (PCI). Design …
artery access for primary or rescue percutaneous coronary intervention (PCI). Design …
Structure–activity relationships for a series of (bis (4-fluorophenyl) methyl) sulfinyl alkyl alicyclic amines at the dopamine transporter: functionalizing the terminal …
RD Slack, TC Ku, J Cao, JLB Giancola… - Journal of medicinal …, 2019 - ACS Publications
Atypical dopamine transporter (DAT) inhibitors have shown therapeutic potential in
preclinical models of psychostimulant abuse. In rats, 1-(4-(2-((bis (4-fluorophenyl) methyl) …
preclinical models of psychostimulant abuse. In rats, 1-(4-(2-((bis (4-fluorophenyl) methyl) …
Effects of (R)-Modafinil and Modafinil Analogues on Dopamine Dynamics Assessed by Voltammetry and Microdialysis in the Mouse Nucleus Accumbens Shell
JD Keighron, JC Quarterman, J Cao… - ACS chemical …, 2019 - ACS Publications
Recent discoveries have improved our understanding of the physiological and pathological
roles of the dopamine transporter (DAT); however, only a few drugs are clinically available …
roles of the dopamine transporter (DAT); however, only a few drugs are clinically available …
Atypical dopamine transporter inhibitors attenuate compulsive-like methamphetamine self-administration in rats
BJ Tunstall, CP Ho, J Cao, JCM Vendruscolo… - …, 2018 - Elsevier
Methamphetamine (METH) is a highly addictive drug, but no pharmacological treatment is
yet available for METH use disorders. Similar to METH, the wake-promoting drug (R) …
yet available for METH use disorders. Similar to METH, the wake-promoting drug (R) …