Objectives: The goal of this study was to determine whether aortic pulse wave velocity
(aPWV) improves prediction of cardiovascular disease (CVD) events beyond conventional …

Summary On Sept 29, 2013, the Framingham Heart Study will celebrate 65 years since the
examination of the first volunteer in 1948. During this period, the study has provided …

echocardiogram) may be expected to facilitate the identification of patients with chest pain of
an ischemic etiology (angina). In a patient presenting to the emergency department with …

Background—Separate multivariable risk algorithms are commonly used to assess risk of
specific atherosclerotic cardiovascular disease (CVD) events, ie, coronary heart disease …

Identification of key factors associated with the risk of developing cardiovascular disease
and quantification of this risk using multivariable prediction algorithms are among the major …

Background Extreme obesity is recognized to be a risk factor for heart failure. It is unclear
whether overweight and lesser degrees of obesity also pose a risk. Methods We …

Background—Vitamin D receptors have a broad tissue distribution that includes vascular
smooth muscle, endothelium, and cardiomyocytes. A growing body of evidence suggests …

Background—Visceral adipose tissue (VAT) compartments may confer increased metabolic
risk. The incremental utility of measuring both visceral and subcutaneous abdominal …

Background Information is limited regarding the risk of cardiovascular disease in persons
with high-normal blood pressure (systolic pressure of 130 to 139 mm Hg, diastolic pressure …

Emerging technologies allow the high-throughput profiling of metabolic status from a blood
specimen (metabolomics). We investigated whether metabolite profiles could predict the …