Developed in 1992, the flow-mediated dilation test is now the most commonly used
noninvasive assessment of vascular endothelial function in humans. Since its inception …

For exercise modalities such as cycling which recruit a substantial muscle mass, muscle
oxygen uptake (V̇O 2) is the primary determinant of pulmonary V̇O 2. Indeed, the kinetic …

The hallmark symptom of chronic heart failure (HF) is severe exercise intolerance. Impaired
perfusive and diffusive O2 transport are two of the major determinants of reduced physical …

The assumption that cellular oxygen pressure (PO2) is close to zero in maximally exercising
muscle is essential for the hypothesis that O2 transport between blood and mitochondria has …

Muscle O2 uptake (VO2) kinetics in response to an augmented energetic requirement (on-
transition) has never been directly determined in humans. We have developed a constant …

In skeletal muscle, phosphocreatine (PCr) recovery from submaximal exercise has become
a reliable and accepted measure of muscle oxidative capacity. During exercise, O2 …

During conventional cycle ergometry, as work rate (WR) is increased toward maximum, O2
extraction increases hyperbolically, typically achieving values of 80–90% at peak O2 uptake …

The purpose of this study was to use31P-magnetic resonance spectroscopy to examine the
relationships among muscle PCr hydrolysis, intracellular H+ concentration accumulation …

It remains controversial whether lactate formation during progressive dynamic exercise from
submaximal to maximal effort is due to muscle hypoxia. To study this question, we used …

This study sought to determine whether afferent feedback associated with peripheral muscle
fatigue inhibits central motor drive (CMD) and thereby limits endurance exercise …