Cell-based therapies for regeneration of intervertebral discs are regarded to hold promise
for degenerative disc disease treatment, a condition that is strongly linked to lower back …

Vascular calcification describes the formation of mineralized tissue within the blood vessel
wall, and it is highly associated with increased cardiovascular morbidity and mortality in …

Background Vascular calcification is associated with increased cardiovascular morbidity and
mortality in patients with atherosclerosis, diabetes and chronic kidney disease. However, no …

Aims Vascular calcification is a major cause of morbidity and mortality. Fibroblast growth
factor-2 (FGF-2) plays an instructive role in osteogenesis and bone development, but its role …

Despite rigorous preclinical and clinical safety evaluation, adverse cardiac effects remain a
leading cause of drug attrition and post-approval drug withdrawal. A number of …

Chronic kidney disease (CKD) is defined as the progressive loss of renal function often
involving glomerular, tubulo-interstitial and vascular pathology. CKD is associated with …

Vascular calcification is the deposition of mineral in the artery wall by vascular smooth
muscle cells (VSMCs) in response to pathological stimuli. The process is similar to bone …

Heart failure (HF) is predominantly a disease of older adults and characterized by extensive
sympatho-vagal imbalance leading to impaired reflex control of heart rate (HR). However …

Arterial medial calcification is an independent risk factor for mortality in chronic kidney
disease. We previously reported that knock-down of PKCα expression increases high …

Intimal calcification is the formation of mineralised tissue within atherosclerotic lesions and
can lead to an increased risk of plaque rupture and mortality in man. Even though …