Dual-energy computed tomography (DECT) has recently been introduced for clinical use.
One potential application of DECT is myocardial perfusion imaging through the significant …

Application of quantitative myocardial CT perfusion (CTP) for the assessment of coronary
artery disease may have a significant effect on patient care as the functional significance of a …

The objective of this study is to assess the effectiveness of physiologically based
pharmacokinetic (PBPK) models for simulating human plasma concentration–time profiles …

Dexmedetomidine–propofol pharmacodynamic interaction was evaluated in nine healthy
subjects in a crossover design. Dexmedetomidine/placebo was infused using a computer …

The objective of this study was to evaluate the performance of various allometric and in vitro–
in vivo extrapolation (IVIVE) methodologies with and without plasma protein binding …

Background & Aims Paritaprevir (administered with ritonavir, PTV/r), ombitasvir (OBV), and
dasabuvir (DSV) are direct-acting antiviral agents (DAAs) for the treatment of chronic …

The development of direct-acting antiviral (DAA) agents has reinvigorated the treatment of
hepatitis C virus infection. The availability of multiple DAA agents and drug combinations …

Dexmedetomidine, a highly selective α2‐adrenoceptor agonist, reduces the requirements
for anesthetic, analgesic, sedative, and hypnotic drugs. Dexmedetomidine pharmacokinetics …

Based on the structure of the original helical FDK algorithm, a three-dimensional (3D)-
weighted cone beam filtered backprojection (CB-FBP) algorithm is proposed for image …

The objective of this study was to evaluate the performance of various empirical,
semimechanistic and mechanistic methodologies with and without protein binding …