Background Inter-individual differences in biological ageing could affect susceptibility to
coronary heart disease. Our aim was to determine whether mean leucocyte telomere length …

Objective—Biological age may be distinct from chronological age and contribute to the
pathogenesis of age-related diseases. Mean telomeres lengths provide an assessment of …

Telomere length is a crucial factor for both normal chromosomal function and senescence.
Mean telomere length in humans shows considerable interindividual variation and strong …

Background—Inflammation plays an important role in the progress of adverse ventricular
remodeling after myocardial infarction. High-mobility group box 1 (HMGB1) is a nuclear …

Background: It has been hypothesised that socioeconomically deprived people age more
rapidly than their more advantaged counterparts and this is biologically manifest in shorter …

Experimental studies have implicated telomere dynamics in cardiomyocyte size and
replication potential; shorter telomeres mark attenuated proliferation and increased …

Telomeres are repetitive sequences of variable length at the ends of chromosomes involved
in maintaining their integrity. Telomere dysfunction is associated with increased risk of …

Renal function impairment relates to poor outcome in patients with chronic heart failure (HF).
Differences in biological aging could affect the susceptibility to develop renal dysfunction in …

Cell transplantation is an emerging therapy for treating post-infarction heart failure. Although
the paracrine effect has been proposed to be an important mechanism for the therapeutic …

Objective: Studies in white people have shown that telomere length, a marker of biological
ageing, is shorter in individuals with coronary artery disease (CAD). South Asian Indians …