Telomere length, risk of coronary heart disease, and statin treatment in the West of Scotland Primary Prevention Study: a nested case-control study
SW Brouilette, JS Moore, AD McMahon, JR Thompson… - The Lancet, 2007 - thelancet.com
Background Inter-individual differences in biological ageing could affect susceptibility to
coronary heart disease. Our aim was to determine whether mean leucocyte telomere length …
coronary heart disease. Our aim was to determine whether mean leucocyte telomere length …
White cell telomere length and risk of premature myocardial infarction
S Brouilette, RK Singh, JR Thompson… - … , and vascular biology, 2003 - Am Heart Assoc
Objective—Biological age may be distinct from chronological age and contribute to the
pathogenesis of age-related diseases. Mean telomeres lengths provide an assessment of …
pathogenesis of age-related diseases. Mean telomeres lengths provide an assessment of …
[PDF][PDF] Mapping of a major locus that determines telomere length in humans
M Vasa-Nicotera, S Brouilette, M Mangino… - The American Journal of …, 2005 - cell.com
Telomere length is a crucial factor for both normal chromosomal function and senescence.
Mean telomere length in humans shows considerable interindividual variation and strong …
Mean telomere length in humans shows considerable interindividual variation and strong …
Modulated inflammation by injection of high-mobility group box 1 recovers post-infarction chronically failing heart
K Takahashi, S Fukushima, K Yamahara, K Yashiro… - Circulation, 2008 - Am Heart Assoc
Background—Inflammation plays an important role in the progress of adverse ventricular
remodeling after myocardial infarction. High-mobility group box 1 (HMGB1) is a nuclear …
remodeling after myocardial infarction. High-mobility group box 1 (HMGB1) is a nuclear …
Socioeconomic status and telomere length: the West of Scotland Coronary Prevention Study
Background: It has been hypothesised that socioeconomically deprived people age more
rapidly than their more advantaged counterparts and this is biologically manifest in shorter …
rapidly than their more advantaged counterparts and this is biologically manifest in shorter …
Association between left ventricular mass and telomere length in a population study
T Kuznetsova, V Codd, S Brouilette… - American journal of …, 2010 - academic.oup.com
Experimental studies have implicated telomere dynamics in cardiomyocyte size and
replication potential; shorter telomeres mark attenuated proliferation and increased …
replication potential; shorter telomeres mark attenuated proliferation and increased …
A regulatory SNP of the BICD1 gene contributes to telomere length variation in humans
M Mangino, S Brouilette, P Braund… - Human molecular …, 2008 - academic.oup.com
Telomeres are repetitive sequences of variable length at the ends of chromosomes involved
in maintaining their integrity. Telomere dysfunction is associated with increased risk of …
in maintaining their integrity. Telomere dysfunction is associated with increased risk of …
Possible association between telomere length and renal dysfunction in patients with chronic heart failure
P van der Harst, LSM Wong, RA de Boer… - The American journal of …, 2008 - Elsevier
Renal function impairment relates to poor outcome in patients with chronic heart failure (HF).
Differences in biological aging could affect the susceptibility to develop renal dysfunction in …
Differences in biological aging could affect the susceptibility to develop renal dysfunction in …
Donor cell-type specific paracrine effects of cell transplantation for post-infarction heart failure
Y Shintani, S Fukushima, A Varela-Carver, J Lee… - Journal of molecular and …, 2009 - Elsevier
Cell transplantation is an emerging therapy for treating post-infarction heart failure. Although
the paracrine effect has been proposed to be an important mechanism for the therapeutic …
the paracrine effect has been proposed to be an important mechanism for the therapeutic …
Association of shorter telomeres with coronary artery disease in Indian subjects
M Mukherjee, S Brouilette, S Stevens, KR Shetty… - Heart, 2009 - heart.bmj.com
Objective: Studies in white people have shown that telomere length, a marker of biological
ageing, is shorter in individuals with coronary artery disease (CAD). South Asian Indians …
ageing, is shorter in individuals with coronary artery disease (CAD). South Asian Indians …