[HTML][HTML] SARS-CoV-2 RNAemia and proteomic trajectories inform prognostication in COVID-19 patients admitted to intensive care

C Gutmann, K Takov, SA Burnap, B Singh, H Ali… - Nature …, 2021 - nature.com
Prognostic characteristics inform risk stratification in intensive care unit (ICU) patients with
coronavirus disease 2019 (COVID-19). We obtained blood samples (n= 474) from …

Association of cardiometabolic microRNAs with COVID-19 severity and mortality

C Gutmann, K Khamina, K Theofilatos… - Cardiovascular …, 2022 - academic.oup.com
Abstract Aims Coronavirus disease 2019 (COVID-19) can lead to multiorgan damage.
MicroRNAs (miRNAs) in blood reflect cell activation and tissue injury. We aimed to …

Neutrophil-derived protein S100A8/A9 alters the platelet proteome in acute myocardial infarction and is associated with changes in platelet reactivity

A Joshi, LE Schmidt, SA Burnap, R Lu… - … and Vascular Biology, 2022 - Am Heart Assoc
Objective: Platelets are central to acute myocardial infarction (MI). How the platelet proteome
is altered during MI is unknown. We sought to describe changes in the platelet proteome …

Uncovering the Role of N-Glycan Occupancy on the Cooperative Assembly of Spike and Angiotensin Converting Enzyme 2 Complexes: Insights from …

TJ El-Baba, CA Lutomski, SA Burnap… - Journal of the …, 2023 - ACS Publications
Interactions between the SARS-CoV-2 Spike protein and ACE2 are one of the most
scrutinized reactions of our time. Yet, questions remain as to the impact of glycans on …

Loss of hepatic miR-33 improves metabolic homeostasis and liver function without altering body weight or atherosclerosis

NL Price, X Zhang… - Proceedings of the …, 2021 - National Acad Sciences
miR-33 is an intronic microRNA within the gene encoding the SREBP2 transcription factor.
Like its host gene, miR-33 has been shown to be an important regulator of lipid metabolism …

ApoCIII-Lp (a) complexes in conjunction with Lp (a)-OxPL predict rapid progression of aortic stenosis

R Capoulade, M Torzewski, M Mayr, KL Chan… - Heart, 2020 - heart.bmj.com
Objective This study assessed whether apolipoprotein CIII-lipoprotein (a) complexes
(ApoCIII-Lp (a)) associate with progression of calcific aortic valve stenosis (AS). Methods …

[HTML][HTML] Mass photometry reveals SARS-CoV-2 spike stabilisation to impede ACE2 binding through altered conformational dynamics

SA Burnap, WB Struwe - Chemical Communications, 2022 - pubs.rsc.org
Here we show using mass photometry how proline substitutions, commonly used for SARS-
CoV-2 spike stabilisation in vaccine design, directly affects ACE2 receptor interactions via …

PCSK9 activity is potentiated through HDL binding

SA Burnap, K Sattler, R Pechlaner, E Duregotti… - Circulation …, 2021 - Am Heart Assoc
Rationale: PCSK9 (proprotein convertase subtilisin/kexin type 9) circulates in a free and
lipoprotein-bound form, yet the functional consequence of the association between PCSK9 …

An N-glycan on the C2 domain of JAGGED1 is important for Notch activation

Y Meng, S Sanlidag, SA Jensen, SA Burnap… - Science …, 2022 - science.org
The canonical members of the Jagged/Serrate and Delta families of transmembrane ligands
have an extracellular, amino-terminal C2 domain that binds to phospholipids and is required …

[HTML][HTML] Reduced secretion of neuronal growth regulator 1 contributes to impaired adipose-neuronal crosstalk in obesity

E Duregotti, CM Reumiller, U Mayr, M Hasman… - Nature …, 2022 - nature.com
While the endocrine function of white adipose tissue has been extensively explored,
comparatively little is known about the secretory activity of less-investigated fat depots. Here …