Role of nuclear factor κB in cardiovascular health and disease

K Van der Heiden, S Cuhlmann, LA Luong… - Clinical …, 2010 - portlandpress.com
Cardiovascular pathologies are still the primary cause of death worldwide. The molecular
mechanisms behind these pathologies have not been fully elucidated. Unravelling them will …

Activation of Nrf2 in endothelial cells protects arteries from exhibiting a proinflammatory state

M Zakkar, K Van der Heiden, LA Luong… - … , and vascular biology, 2009 - Am Heart Assoc
Objective—Proinflammatory mediators influence atherosclerosis by inducing adhesion
molecules (eg, VCAM-1) on endothelial cells (ECs) via signaling intermediaries including …

Disturbed blood flow induces RelA expression via c-Jun N-terminal kinase 1: a novel mode of NF-κB regulation that promotes arterial inflammation

S Cuhlmann, K Van der Heiden, D Saliba… - Circulation …, 2011 - Am Heart Assoc
Rationale: The nuclear factor (NF)-κB pathway is involved in arterial inflammation. Although
the signaling pathways that regulate transcriptional activation of NF-κB are defined, the …

Increased endothelial mitogen-activated protein kinase phosphatase-1 expression suppresses proinflammatory activation at sites that are resistant to atherosclerosis

M Zakkar, H Chaudhury, G Sandvik, K Enesa… - Circulation …, 2008 - Am Heart Assoc
Atherosclerosis is a chronic inflammatory disease of arteries. It is triggered by
proinflammatory mediators which induce adhesion molecules (eg, vascular cell adhesion …

Shear stress modulates the expression of the atheroprotective protein Cx37 in endothelial cells

A Pfenniger, C Wong, E Sutter, S Cuhlmann… - Journal of molecular and …, 2012 - Elsevier
High laminar shear stress (HLSS) is vasculoprotective partly through induction of Kruppel-
like factor 2 (KLF2). Connexin37 (Cx37) is highly expressed in endothelial cells (ECs) of …

c-Jun N-terminal kinase primes endothelial cells at atheroprone sites for apoptosis

H Chaudhury, M Zakkar, J Boyle… - … , and vascular biology, 2010 - Am Heart Assoc
Objective—Atherosclerosis is a focal disease that occurs predominantly at branches and
bends of the arterial tree. Endothelial cells (EC) at atherosusceptible sites are prone to …

[HTML][HTML] Disturbed flow induces a sustained, stochastic NF-κB activation which may support intracranial aneurysm growth in vivo

DC Baeriswyl, I Prionisti, T Peach, G Tsolkas… - Scientific reports, 2019 - nature.com
Intracranial aneurysms are associated with disturbed velocity patterns, and chronic
inflammation, but the relevance for these findings are currently unknown. Here, we show that …

In Vivo Mapping of Vascular Inflammation Using the Translocator Protein Tracer 18F-FEDAA1106

S Cuhlmann, W Gsell, K Van der Heiden… - Molecular …, 2014 - journals.sagepub.com
Noninvasive imaging methods are required to monitor the inflammatory content of
atherosclerotic plaques. FEDAA1106 (N-(5-fluoro-2-phenoxyphenyl)-N-(2-(2-fluoroethoxy)-5 …

[HTML][HTML] Loss of vps54 function leads to vesicle traffic impairment, protein mis-sorting and embryonic lethality

P Karlsson, A Droce, JM Moser, S Cuhlmann… - International journal of …, 2013 - mdpi.com
The identification of the mutation causing the phenotype of the amyotrophic lateral sclerosis
(ALS) model mouse, wobbler, has linked motor neuron degeneration with retrograde vesicle …

Control of tissue morphology by Fasciclin III-mediated intercellular adhesion

RE Wells, JD Barry, SJ Warrington… - …, 2013 - journals.biologists.com
Morphogenesis is dependent on the orchestration of multiple developmental processes to
generate mature functional organs. However, the signalling pathways that coordinate …