Objectives: We investigated the occurrence of pharmacodynamic interaction between low-
dose aspirin and naproxen. Background: The uncertainty of cardioprotection by naproxen …

We provide comprehensive knowledge on the differential regulation of expression and
catalysis of cyclooxygenase (COX)-1 and COX-2 in health and disease which represents an …

Aspirin taken for several years at doses of at least 75 mg daily reduced long-term incidence
and mortality due to colorectal cancer. The finding of aspirin benefit at low-doses given once …

Objectives: We studied the association between the frequency, dose, and duration of
different nonsteroidal anti-inflammatory drugs (NSAIDs) and the risk of myocardial infarction …

Objective Traditional nonsteroidal antiinflammatory drugs (NSAIDs) increase the risk of
upper gastrointestinal (GI) bleeding/perforation, but the magnitude of this effect for coxibs in …

Background—Hypertensive patients with renovascular disease (RVD) may be exposed to
increased oxidative stress, possibly related to activation of the renin-angiotensin system …

Background—The current controversy on the potential cardioprotective effect of naproxen
prompted us to evaluate the extent and duration of platelet, monocyte, and vascular …

Conventional medical treatment for rheumatoid arthritis and osteoarthritis includes the use of
NSAIDs (traditional and selective inhibitors of cyclooxygenase [COX]-2), because they …

Diabetes mellitus is associated with platelet hyperactivity, which leads to increased
morbidity and mortality from cardiovascular disease. This is coupled with enhanced levels of …

It is now established that prostanoids play important roles in many cellular responses and
pathophysiologic processes including modulation of the inflammatory reaction, erosion of …