Habitual physical activity is associated with intrahepatic fat content in humans

…, G Ntali, A Esposito, E Belloni, T Canu… - Diabetes …, 2007 - Am Diabetes Assoc
OBJECTIVE—Fatty liver may be involved in the pathogenesis of type 2 diabetes. Physical
exercise is a tool to improve insulin sensitivity, but little is known about its effect on …

Delayed gadolinium-enhanced cardiac magnetic resonance in patients with chronic myocarditis presenting with heart failure or recurrent arrhythmias

…, C Chimenti, E Belloni, R Mellone, T Canu… - Journal of the American …, 2006 - jacc.org
Objectives: We evaluated the effectiveness of contrast-enhanced cardiac magnetic
resonance (CE-CMR) in detecting chronic myocarditis (CM). Background: Chronic …

[PDF][PDF] Increased mediastinal fat and impaired left ventricular energy metabolism in young men with newly found fatty liver

…, E Belloni, G Ntali, F Ragogna, T Canu… - …, 2008 - Wiley Online Library
Fatty liver is characterized by metabolic abnormalities at the liver, but also at skeletal muscle
and adipose tissue sites. It is hypothesized that the heart may be suffering metabolic …

Targeted inducible delivery of immunoactivating cytokines reprograms glioblastoma microenvironment and inhibits growth in mouse models

…, M Callea, R Norata, L Chaabane, T Canu… - Science translational …, 2022 - science.org
Glioblastoma multiforme (GBM) is the most common and lethal brain tumor characterized by
a strongly immunosuppressive tumor microenvironment (TME) that represents a barrier also …

2-Deoxy-d-glucose ameliorates PKD progression

…, I Rowe, V Mannella, G Quilici, T Canu… - Journal of the …, 2016 - journals.lww.com
Autosomal dominant polycystic kidney disease (ADPKD) is an important cause of ESRD for
which there exists no approved therapy in the United States. Defective glucose metabolism …

Maturing dendritic cells depend on RAGE for in vivo homing to lymph nodes

…, A Esposito, F De Cobelli, T Canu… - The Journal of …, 2008 - journals.aai.org
The mobilization of dendritic cells (DCs) from peripheral tissues is critical for the
establishment of T cell-dependent immune responses or tolerance, because the physical …

Insulin resistance and whole body energy homeostasis in obese adolescents with fatty liver disease

…, G Lattuada, F De Cobelli, T Canu… - American Journal …, 2006 - journals.physiology.org
Obese adolescents are at risk of developing NAFLD and type 2 diabetes. We measured
noninvasively the IHF content of obese adolescents to ascertain whether it is associated with …

[HTML][HTML] Reduced intrahepatic fat content is associated with increased whole-body lipid oxidation in patients with type 1 diabetes

…, F De Cobelli, A Esposito, F Costantino, T Canu… - Diabetologia, 2005 - Springer
Aims/hypothesis Insulin resistance may be associated with ectopic fat accumulation
potentially determined by reduced lipid oxidation. In patients with type 1 diabetes peripheral …

On the use of superparamagnetic hydroxyapatite nanoparticles as an agent for magnetic and nuclear in vivo imaging

…, M Iafisco, M Sandri, M Basini, P Arosio, T Canu… - Acta biomaterialia, 2018 - Elsevier
The identification of alternative biocompatible magnetic NPs for advanced clinical
application is becoming an important need due to raising concerns about iron accumulation …

[PDF][PDF] In vivo macrophage engineering reshapes the tumor microenvironment leading to eradication of liver metastases

…, C Bresesti, M Notaro, GM Scotti, C Balestrieri, T Canu… - Cancer Cell, 2023 - cell.com
Liver metastases are associated with poor response to current pharmacological treatments,
including immunotherapy. We describe a lentiviral vector (LV) platform to selectively …