Background—High-throughput profiling of circulating metabolites may improve
cardiovascular risk prediction over established risk factors. Methods and Results—We …

Characterizing genetic influences on DNA methylation (DNAm) provides an opportunity to
understand mechanisms underpinning gene regulation and disease. In the present study …

Background Metformin might reduce insulin requirement and improve glycaemia in patients
with type 1 diabetes, but whether it has cardiovascular benefits is unknown. We aimed to …

Background Higher circulating levels of the branched-chain amino acids (BCAAs; ie,
isoleucine, leucine, and valine) are strongly associated with higher type 2 diabetes risk, but …

Aims/hypothesis We examined prospectively whether measured risk factors can explain the
higher CHD mortality in South Asians compared with Europeans. Materials and methods …

Background DNA methylation is strongly associated with smoking status at multiple sites
across the genome. Studies have largely been restricted to European origin individuals yet …

Aims/hypothesis The aim of this study was to study differences in the prevalence of the
metabolic syndrome and its associations with prevalent CHD according to ethnicity and sex …

Background Early menopause is linked to an increased risk of cardiovascular disease
mortality; however, the association between early menopause and incidence and timing of …

Objectives: This study sought to determine whether ethnic differences in diabetes,
dyslipidemia, and ectopic fat deposition account for ethnic differences in incident …

Background Biological aging estimators derived from DNA methylation data are heritable
and correlate with morbidity and mortality. Consequently, identification of genetic and …