Fractal and complexity measures of heart rate variability

JS Perkiömäki, TH Mäkikallio… - Clinical and experimental …, 2005 - Taylor & Francis
Heart rate variability has been analyzed conventionally with time and frequency domain
methods, which measure the overall magnitude of RR interval fluctuations around its mean …

Sudden cardiac death: role of heart rate variability to identify patients at risk

F Lombardi, TH Mäkikallio, RJ Myerburg… - Cardiovascular …, 2001 - academic.oup.com
1. Introduction of available methodologies, limitations of the study designs and of future
directions in HR variability utilisation Sudden, unexpected cardiac death stands as one of …

Heart rate variability in ischemic heart disease

HV Huikuri, TH Mäkikallio - Autonomic Neuroscience, 2001 - Elsevier
Major untoward events, such as life-threatening arrhythmias and acute coronary events,
have been suggested to be triggered by the activation of the autonomic nervous system in …

Fractal correlation properties of RR interval dynamics and mortality in patients with depressed left ventricular function after an acute myocardial infarction

HV Huikuri, TH Mäkikallio, CK Peng, AL Goldberger… - Circulation, 2000 - Am Heart Assoc
Background—Preliminary data suggest that the analysis of RR interval variability by fractal
analysis methods may provide clinically useful information on patients with heart failure. The …

Cardiac interbeat interval dynamics from childhood to senescence: comparison of conventional and new measures based on fractals and chaos theory

SM Pikkujämsä, TH Mäkikallio, LB Sourander… - Circulation, 1999 - Am Heart Assoc
Background—New methods of RR interval variability based on fractal scaling and nonlinear
dynamics (“chaos theory”) may give new insights into heart rate dynamics. The aims of this …

Fractal analysis of heart rate dynamics as a predictor of mortality in patients with depressed left ventricular function after acute myocardial infarction

TH Mäkikallio, S Høiber, L Køber… - The American journal of …, 1999 - Elsevier
A number of new methods have been recently developed to quantify complex heart rate
(HR) dynamics based on nonlinear and fractal analysis, but their value in risk stratification …

Fractal analysis of heart rate variability and mortality after an acute myocardial infarction

JM Tapanainen, PEB Thomsen, L Køber… - The American journal of …, 2002 - Elsevier
The recently developed fractal analysis of heart rate (HR) variability has been suggested to
provide prognostic information about patients with heart failure. This prospective multicenter …

Prediction of sudden cardiac death by fractal analysis of heart rate variability in elderly subjects

TH Mäkikallio, HV Huikuri, A Mäkikallio… - Journal of the American …, 2001 - jacc.org
OBJECTIVES The aim of this study was to test the hypothesis that abnormal scaling
characteristics of heart rate (HR) predict sudden cardiac death in a random population of …

Prediction of sudden cardiac death after acute myocardial infarction: role of Holter monitoring in the modern treatment era

TH Mäkikallio, P Barthel, R Schneider… - European heart …, 2005 - academic.oup.com
Aims Current treatment may have changed the risk profiles of survivors of acute myocardial
infarction (AMI). We evaluated the utility of Holter-based risk variables in the prediction of …

Changes in cardiac autonomic regulation after prolonged maximal exercise

A Hautala, MP Tulppo, TH Mäkikallio… - Clinical …, 2001 - Wiley Online Library
Harmful cardiac events occurs frequently after exercise. However, the cardiac autonomic
regulation after vigorous exercise is not well known. This study was designed to assess …