Research which started more than a decade ago in such diverse fields as receptor-mediated
increases in cyclic GMP levels in the central nervous system [1], the search for nitrate …

The beneficial actions of nonsteroidal anti‐inflammatory drugs (NSAIDs) have been linked to
their ability to inhibit inducible COX‐2 at sites of inflammation, and their side effects (eg …

Humans have been using nonsteroid antiinf lammatory drugs (NSAIDs) in various forms for
more than 3,500 years (1). They are still our favorite medicines. Estimates vary, but it …

Endothelin releases prostacyclin and thromboxane A2 from guinea pig or rat isolated lungs
and endothelium-derived relaxing factor in the perfused mesentery of the rat. Endothelin is …

The beneficial actions of nonsteroid anti-inflammatory drugs (NSAID) can be associated with
inhibition of cyclo-oxygenase (COX)-2 whereas their harmful side effects are associated with …

The particulate enzyme responsible for the synthesis of endothelium-derived relaxing factor
has been purified from cultured and native (noncultured) bovine aortic endothelial cells …

Rationale: MicroRNA (miRNA) biomarkers are attracting considerable interest. Effects of
medication, however, have not been investigated thus far. Objective: To analyze changes in …

L-Arginine causes insulin release from pancreatic B cells. Data from three model systems
support the hypothesis that L-arginine-derived nitrogen oxides (NOs) mediate insulin …

Cyclo‐oxygenase is expressed in cells in two distinct isoforms. Cyclo‐oxygenase‐1 is
present constitutively whilst cyclo‐oxygenase‐2 is expressed primarily after inflammatory …

Objective—The role of the nuclear receptor peroxisome-proliferator activated receptor
(PPAR)-β/δ in endothelial cells remains unclear. Interestingly, the selective PPARβ/δ ligand …