Sorting an LDL receptor with bound PCSK9 to intracellular degradation
TP Leren - Atherosclerosis, 2014 - Elsevier
Objective This article reviews the mechanism by which the low density lipoprotein receptor
(LDLR) that has bound proprotein convertase subtilisin/kexin type 9 (PCSK9), is rerouted to …
(LDLR) that has bound proprotein convertase subtilisin/kexin type 9 (PCSK9), is rerouted to …
Application of molecular genetics for diagnosing familial hypercholesterolemia in Norway: results from a family-based screening program
TP Leren, T Manshaus, U Skovholt… - Seminars in vascular …, 2004 - thieme-connect.com
ABSTRACT A total of 119 different mutations in the low-density lipoprotein-receptor gene
have so far been found to cause familial hypercholesterolemia (FH) among Norwegian …
have so far been found to cause familial hypercholesterolemia (FH) among Norwegian …
Effect of mutations in the PCSK9 gene on the cell surface LDL receptors
J Cameron, ØL Holla, T Ranheim… - Human molecular …, 2006 - academic.oup.com
The proprotein convertase subtilisin/kexin type 9 (PCSK9) gene is involved in the post-
transcriptional regulation of the low-density lipoprotein (LDL) receptors (LDLR). Mutations in …
transcriptional regulation of the low-density lipoprotein (LDL) receptors (LDLR). Mutations in …
Risk factors related to carotid intima-media thickness and plaque in children with familial hypercholesterolemia and control subjects
S Tonstad, O Joakimsen… - … , and vascular biology, 1996 - Am Heart Assoc
To assess the relationship between risk factors for cardiovascular disease and early
atherosclerotic changes in the carotid artery, we measured carotid intima-media thickness …
atherosclerotic changes in the carotid artery, we measured carotid intima-media thickness …
Missense mutations in the PCSK9 gene are associated with hypocholesterolemia and possibly increased response to statin therapy
KE Berge, L Ose, TP Leren - Arteriosclerosis, thrombosis, and …, 2006 - Am Heart Assoc
Objective—The proprotein convertase subtilisin/kexin type 9 (PCSK9) gene encodes a
proprotein convertase that causes degradation of cell surface low-density lipoprotein …
proprotein convertase that causes degradation of cell surface low-density lipoprotein …
Berberine decreases PCSK9 expression in HepG2 cells
J Cameron, T Ranheim, MA Kulseth, TP Leren… - Atherosclerosis, 2008 - Elsevier
BACKGROUND: Proprotein convertase subtilisin/kexin type 9 (PCSK9) post-transcriptionally
downregulates the low-density lipoprotein receptor (LDLR) by binding to the receptor's …
downregulates the low-density lipoprotein receptor (LDLR) by binding to the receptor's …
Right ventricular mechanical dispersion is related to malignant arrhythmias: a study of patients with arrhythmogenic right ventricular cardiomyopathy and subclinical …
SI Sarvari, KH Haugaa, OG Anfinsen… - European heart …, 2011 - academic.oup.com
Aims We evaluated if right ventricular (RV) mechanical dispersion by strain was related to
ventricular arrhythmias (VT/VF) in patients with arrhythmogenic right ventricular …
ventricular arrhythmias (VT/VF) in patients with arrhythmogenic right ventricular …
Development of sensitive and specific age-and gender-specific low-density lipoprotein cholesterol cutoffs for diagnosis of first-degree relatives with familial …
B Starr, SG Hadfield, BA Hutten… - Clinical chemistry and …, 2008 - degruyter.com
Background: The plasma total and low-density lipoprotein-cholesterol (LDL-C) levels that
are used as diagnostic criteria for familial hypercholesterolaemia (FH) probands in the …
are used as diagnostic criteria for familial hypercholesterolaemia (FH) probands in the …
Prospective, population-based long QT molecular autopsy study of postmortem negative sudden death in 1 to 40 year olds
JR Skinner, J Crawford, W Smith, A Aitken, D Heaven… - Heart Rhythm, 2011 - Elsevier
BACKGROUND: Retrospective investigation of sudden unexplained death in the young
(SUDY) reveals that a high proportion is due to inherited heart disease. OBJECTIVE: The …
(SUDY) reveals that a high proportion is due to inherited heart disease. OBJECTIVE: The …
Mortality among patients with familial hypercholesterolemia: A registry‐based study in Norway, 1992–2010
L Mundal, M Sarancic, L Ose, PO Iversen… - Journal of the …, 2014 - Am Heart Assoc
Background Untreated patients with familial hypercholesterolemia are at increased risk of
premature cardiovascular death. The primary aim of this study was to investigate whether …
premature cardiovascular death. The primary aim of this study was to investigate whether …