There has been a recent global resurgence of tuberculosis in both resource—limited and
some resource—rich countries. Several factors have contributed to this resurgence …

A number of potential candidate genes in a variety of biological pathways have been
associated with longevity in model organisms. Many of these genes have human homologs …

Background Invasive aspergillosis is an uncommon but life-threatening event in the
immunocompromised child. Attempts at fungal isolation are often unrewarding and a high …

Within-patient HIV evolution reflects the strong selection pressure driving viral escape from
cytotoxic T-lymphocyte (CTL) recognition. Whether this intrapatient accumulation of escape …

The immunogenetic basis of severe infections caused by bacille Calmette-Guérin vaccine
and environmental mycobacteria in humans remains largely unknown. We describe 18 …

Background Frontotemporal dementia (FTD) is a complex disorder characterised by a broad
range of clinical manifestations, differential pathological signatures, and genetic variability …

Interleukin-12 receptor A1 (IL-12RA1) deficiency is the most common form of Mendelian
susceptibility to mycobacterial disease (MSMD). We undertook an international survey of …

Background—Brugada syndrome (BrS) primarily associates with the loss of sodium channel
function. Previous studies showed features consistent with sodium current (I Na) deficit in …

Objective: To review our experience of central nervous system (CNS) tuberculosis at a major
British paediatric tertiary referral centre, following the introduction of CT Scan facilities …

Background: Long QT syndrome (LQTS) is the first described and most common inherited
arrhythmia. Over the last 25 years, multiple genes have been reported to cause this …