Estrogen and androgen are synthesized from cholesterol locally in hippocampal neurons of
adult animals. These neurosteroids are synthesized by cytochrome P450s and …

The hippocampus is a center for learning and memory as well as a target of Alzheimer's
disease in aged humans. Synaptic modulation by estrogen is essential to understand the …

The hippocampus synthesizes estrogen and androgen in addition to the circulating sex
steroids. Synaptic modulation by hippocampus-derived estrogen or androgen is essential to …

In adult mammalian brain, occurrence of the synthesis of estradiol from endogenous
cholesterol has been doubted because of the inability to detect dehydroepiandrosterone …

Neurosteroidogenesis has not been well elucidated due to the very low level of
steroidogenic proteins in the brain. Here we report the first demonstration of the neuronal …

Rapid modulation of hippocampal synaptic plasticity by estrogen has long been a hot topic,
but analysis of molecular mechanisms via synaptic estrogen receptors has been seriously …

OBJECTIVE The purpose of this study was to investigate the clinical significance of vascular
endothelial growth factor (VEGF) in acute myocardial infarction (AMI). We also examined the …

Previous studies showed that the epidermal growth factor receptor (EGFR) can be
transactivated by platelet-derived growth factor (PDGF) stimulation and that EGFR …

Synaptic plasticity of the female hippocampus may cyclically fluctuate across the estrous
cycle. The spine density fluctuation had been explained by fluctuation of plasma estradiol …

Estradiol (E2) and other sex steroids play essential roles in the modulation of synaptic
plasticity and neuroprotection in the hippocampus. To clarify the mechanisms for these …