JCS 2018 guideline on diagnosis and treatment of acute coronary syndrome

K Kimura, T Kimura, M Ishihara, Y Nakagawa… - Circulation …, 2019 - jstage.jst.go.jp
Acute coronary syndromes (ACS) are a comprehensive disease concept characterized by
acute myocardial ischemia caused by disruption of coronary artery plaque and consequent …

Heart failure, chronic kidney disease, and biomarkers–an integrated viewpoint–

Y Iwanaga, S Miyazaki - Circulation Journal, 2010 - jstage.jst.go.jp
Biomarkers in Heart Failure and Kidney Disease which the primary failing organ can be
either the heart or the kidney. Recently, Ronco et al discussed the different heart–kidney …

Fibulin-5/DANCE is essential for elastogenesis in vivo

T Nakamura, PR Lozano, Y Ikeda, Y Iwanaga, A Hinek… - Nature, 2002 - nature.com
The elastic fibre system has a principal role in the structure and function of various types of
organs that require elasticity, such as large arteries, lung and skin,. Although elastic fibres …

B-type natriuretic peptide strongly reflects diastolic wall stress in patients with chronic heart failure: comparison between systolic and diastolic heart failure

Y Iwanaga, I Nishi, S Furuichi, T Noguchi… - Journal of the American …, 2006 - jacc.org
Objectives: We explored the stimulus for B-type natriuretic peptide (BNP) secretion in the
clinical setting of heart failure (HF). Background: Increasingly, plasma BNP levels are being …

MicroRNA-33 encoded by an intron of sterol regulatory element-binding protein 2 (Srebp2) regulates HDL in vivo

T Horie, K Ono, M Horiguchi, H Nishi… - Proceedings of the …, 2010 - National Acad Sciences
Sterol regulatory element-binding protein 2 (SREBP-2) transcription factor has been
identified as a key protein in cholesterol metabolism through the transactivation of the LDL …

Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene delivery

M Hoshijima, Y Ikeda, Y Iwanaga, S Minamisawa… - Nature medicine, 2002 - nature.com
The feasibility of gene therapy for cardiomyopathy, heart failure and other chronic cardiac
muscle diseases is so far unproven. Here, we developed an in vivo recombinant adeno …

Analysis of metabolic remodeling in compensated left ventricular hypertrophy and heart failure

T Kato, S Niizuma, Y Inuzuka, T Kawashima… - Circulation: Heart …, 2010 - Am Heart Assoc
Background—Congestive heart failure (CHF) is associated with a change in cardiac energy
metabolism. However, the mechanism by which this change is induced and causes the …

Twenty-year change in severity and outcome of ischemic and hemorrhagic strokes

K Toyoda, S Yoshimura, M Nakai, M Koga… - JAMA …, 2022 - jamanetwork.com
Importance Whether recent changes in demographic characteristics and therapeutic
technologies have altered stroke outcomes remains unknown. Objective To determine …

[HTML][HTML] Renocardiovascular biomarkers: from the perspective of managing chronic kidney disease and cardiovascular disease

S Niizuma, Y Iwanaga, T Yahata… - Frontiers in cardiovascular …, 2017 - frontiersin.org
Mortality among the patients with chronic kidney disease (CKD) and end-stage renal
disease (ESRD) remains high because of the very high incidence of cardiovascular disease …

Increased expression of interleukin-1β and monocyte chemotactic and activating factor/monocyte chemoattractant protein-1 in the hypertrophied and failing heart with …

T Shioi, A Matsumori, Y Kihara, M Inoko, K Ono… - Circulation …, 1997 - Am Heart Assoc
Studies on the effects of proinflammatory cytokines on the heart suggest that they play some
roles in the pathogenesis of congestive heart failure (CHF). To determine the involvement of …