The vascular endothelium is involved in the release of various vasodilators, including nitric
oxide (NO), prostacyclin and endothelium-derived hyperpolarizing factor, as well as …

Recent epidemiologic studies have shown that aerobic exercise, one of lifestyle
modifications, reduces cardiovascular morbidity and mortality in the general population …

Hypertension is one of the common diseases in the elderly. The prevalence of hypertension
markedly increases with advancing age. Both aging and hypertension have a critical role in …

Background—Aerobic exercise enhances endothelium-dependent vasodilation in
hypertensive patients, patients with chronic heart failure, and healthy individuals. However, it …

Background—Several nonpharmacological interventions, including exercise, are
recommended in primary prevention of hypertension and other cardiovascular diseases in …

Background It has been reported that renovascular hypertension activates the renin–
angiotensin system, leading to an increase in oxidative stress. We sought to determine …

Mesenchymal stem cell (MSC) transplantation is used for treatment of many diseases. The
paracrine role of MSCs in tissue regeneration is attracting particular attention. We …

Background—Patients with limb ischemia were associated with endothelial dysfunction. The
purpose of this study was to determine whether autologous bone-marrow mononuclear cell …

Paracrine signaling by bone-marrow-derived mesenchymal stem cells (MSCs) plays a major
role in tissue repair. Although the production of regulatory cytokines by MSC transplantation …

Excessive dietary phosphorus may increase cardiovascular risk in healthy individuals as
well as in patients with chronic kidney disease, but the mechanisms underlying this risk are …