Diabetes, oxidative stress and therapeutic strategies

L Rochette, M Zeller, Y Cottin, C Vergely - Biochimica et Biophysica Acta …, 2014 - Elsevier
Background Diabetes has emerged as a major threat to health worldwide. Scope of Review
The exact mechanisms underlying the disease are unknown; however, there is growing …

Central obesity and survival in subjects with coronary artery disease: a systematic review of the literature and collaborative analysis with individual subject data

T Coutinho, K Goel, D Corrêa de Sá… - Journal of the American …, 2011 - jacc.org
Objectives: The aim of this study was to examine the association of central (waist
circumference [WC] and waist-hip ratio [WHR]) and total obesity (body mass index [BMI]) …

Nitric oxide synthase inhibition and oxidative stress in cardiovascular diseases: possible therapeutic targets?

L Rochette, J Lorin, M Zeller, JC Guilland… - Pharmacology & …, 2013 - Elsevier
Nitric oxide (radical dot NO) is synthetized enzymatically from l-arginine (l-Arg) by three NO
synthase isoforms, iNOS, eNOS and nNOS. The synthesis of NO is selectively inhibited by …

Postconditioning the human heart

P Staat, G Rioufol, C Piot, Y Cottin, TT Cung… - Circulation, 2005 - Am Heart Assoc
Background—In animal models, brief periods of ischemia performed just at the time of
reperfusion can reduce infarct size, a phenomenon called postconditioning. In this …

[HTML][HTML] Cyclosporine before PCI in patients with acute myocardial infarction

TT Cung, O Morel, G Cayla, G Rioufol… - … England Journal of …, 2015 - Mass Medical Soc
Background Experimental and clinical evidence suggests that cyclosporine may attenuate
reperfusion injury and reduce myocardial infarct size. We aimed to test whether cyclosporine …

Comparison of thrombolysis followed by broad use of percutaneous coronary intervention with primary percutaneous coronary intervention for ST-segment–elevation …

N Danchin, P Coste, J Ferrières, PG Steg, Y Cottin… - Circulation, 2008 - Am Heart Assoc
Background—Intravenous thrombolysis remains a widely used treatment for ST-elevation
myocardial infarction; however, it carries a higher risk of reinfarction than primary PCI …

Acute myocardial infarction: changes in patient characteristics, management, and 6-month outcomes over a period of 20 years in the FAST-MI program (French …

E Puymirat, T Simon, G Cayla, Y Cottin, M Elbaz… - Circulation, 2017 - Am Heart Assoc
Background: ST-segment–elevation myocardial infarction (STEMI) and non–ST-segment–
elevation myocardial infarction (NSTEMI) management has evolved considerably over the …

Combining body mass index with measures of central obesity in the assessment of mortality in subjects with coronary disease: role of “normal weight central obesity”

T Coutinho, K Goel, D Corrêa de Sá, RE Carter… - Journal of the American …, 2013 - jacc.org
Objectives: This study sought to assess the mortality risk of patients with coronary artery
disease (CAD) based on a combination of body mass index (BMI) and measures of central …

[HTML][HTML] Multivessel PCI guided by FFR or angiography for myocardial infarction

E Puymirat, G Cayla, T Simon, PG Steg… - … England Journal of …, 2021 - Mass Medical Soc
Background In patients with ST-elevation myocardial infarction (STEMI) who have
multivessel disease, percutaneous coronary intervention (PCI) for nonculprit lesions …

Direct and indirect antioxidant properties of α‐lipoic acid and therapeutic potential

L Rochette, S Ghibu, C Richard, M Zeller… - Molecular nutrition & …, 2013 - Wiley Online Library
Diabetes has emerged as a major threat to worldwide health. The exact mechanisms
underlying the disease are unknown; however, there is growing evidence that the excess …