The number of patients with type 2 diabetes is increasing rapidly in both developed and
developing countries around the world. The emerging pandemic is driven by the combined …

Objective To provide an overview of prediction models for risk of cardiovascular disease
(CVD) in the general population. Design Systematic review. Data sources Medline and …

Objective: Loss of ovarian function and subsequent deficiency of endogenous estrogens is
suggested to enhance cardiovascular disease risk and related death after menopause. The …

Background High plasma HDL cholesterol is associated with reduced risk of myocardial
infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes …

Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide.
To date, identification of common genetic variants influencing blood pressure has proven …

The genetic architecture of common traits, including the number, frequency, and effect sizes
of inherited variants that contribute to individual risk, has been long debated. Genome-wide …

Background Low-risk limits recommended for alcohol consumption vary substantially across
different national guidelines. To define thresholds associated with lowest risk for all-cause …

Importance The prevalence of cardiometabolic multimorbidity is increasing. Objective To
estimate reductions in life expectancy associated with cardiometabolic multimorbidity …

Background Statins increase the risk of new-onset type 2 diabetes mellitus. We aimed to
assess whether this increase in risk is a consequence of inhibition of 3-hydroxy-3 …

Objective To examine whether adherence to the modified Mediterranean diet, in which
unsaturates were substituted for monounsaturates, is associated with longer life expectancy …