AORTIC STENOSIS

This disease process eventually leads to increased leaflet thickness and stiffness, resulting in left ventricular outflow obstruction and the clinical presentation of the patient with valvar aortic stenosis. In patients with an anatomically normal trileaflet aortic valve, this process occurs in only a subset of patients with symptoms typically occurring at age 70–80 years. Clinical factors associated with atherosclerosis are also associated with calcific aortic valve disease, including age, sex, hypertension, raised serum cholesterol concentration, smoking, and diabetes.^11,12 However, the specific factors that initiate this disease process have not been well defined. By analogy with atherosclerosis, our underlying assumption is that endothelial disruption occurs, possibly caused by low shear stress on the aortic side of the valve. Low shear stress might explain why the calcific process often is seen first and most severely on the non-coronary cusp.

Mechanical or tensile stress on the valve leaflets also has been proposed as an important factor in initiation of the disease process. The major evidence for this hypothesis is that calcific disease occurs at an earlier age in patients with a bicuspid valve, typically with symptoms occurring at 50–60 years of age.¹³ Also, in contrast to the small number of patients with a trileaflet valve that develop severe stenosis, nearly all patients with a bicuspid valve will develop significant outflow tract obstruction. Because the stress–strain relations of a bicuspid valve are abnormal, this higher tensile stress may contribute to earlier initiation and more rapid progression of disease. However, the disease process at the tissue level in bicuspid aortic valves has not been specifically examined, until now.

In this issue of Heart, the study by Wallby and colleagues¹⁴ is the first to compare the disease process at the tissue level in bicuspid and in trileaflet valves in patients with severe stenosis undergoing aortic valve replacement. They observed that T lymphocyte infiltration was present in both bicuspid and trileaflet aortic valves, with a similar pattern and extent of T lymphocytes in the stenotic valve leaflets. Their observations confirm the hypothesis that the disease process is the same in trileaflet and bicuspid valves, again suggesting the differences in clinical presentation are related to the mechanical characteristics of the valve. Although this study examined only valves removed at surgery, extrapolating from previous studies on trileaflet valves, severe calcific valve disease represents the extreme end of a disease spectrum that ranges from mild irregular valve thickening (or sclerosis) to severe valve obstruction.

CLINICAL IMPLICATIONS

These findings have important clinical implications. A bicuspid aortic valve is present in 1–2% of the population and most of these patients will eventually develop stenosis, requiring valve surgery. A minority of patients develop aortic regurgitation as a young adult but the majority have progressive valve stenosis, with only about 1% maintaining normal valve function over their lifetime.¹³ Many of these patients are diagnosed early in life, based on the physical finding of an ejection click or systolic murmur, with echocardiography allowing reliable identification of the number of valve leaflets. There may be a genetic predisposition to a bicuspid valve, possibly allowing family screening.¹⁵ If an effective treatment to prevent inflammation and lipid deposition in the valve leaflets were available, patients with a bicuspid valve could begin treatment at the time of diagnosis, delaying or avoiding the need for valve replacement surgery. At this time, such an intervention is not available, although our understanding of the disease process at the tissue level and the known clinical associations suggest that treatment directed at the disease process in the leaflets may be possible in the future.¹⁶

In the meanwhile, since the disease process in bicuspid and trileaflet valves appear similar and because most patients with a bicuspid valve eventually need surgery, aggressive evaluation and treatment of conventional coronary risk factors is indicated in all patients with a bicuspid aortic valve. Although the effect of this treatment on the aortic valve itself will not be known until randomised clinical trials are performed, at the very least we will be decreasing the likelihood that concurrent coronary artery bypass grafting will be needed at the time of valve replacement.