eLetters

773 e-Letters

  • Re: Coronary endothelial dysfunction after Kawasaki disease
    Masahiro Ishii

    Dear Editor:

    We appreciate the kind comments of Dr Mitani regarding our article in the March 2000 issue of Heart and for sharing their experiences with us.[1]

    In group 1 and 2 patients who had regressed coronary aneurysm after Kawasaki disease, there was significantly more vascular constriction with acetylcholine and poorer dilatation with isosorbide dinitrate at the regressed site, than in group 3 patient...

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  • Application of clinical trial results
    Pitt O Lim

    Dear Editor:

    I read with interest Kübler’s review[1] and Willenheimer and colleagues’ viewpoint[2] on a similar theme about the application of drug trial results in clinical practice, an area that remains controversial.

    Florey’s penicillin trial in the 1940s only involved 8 mice. The mice were inoculated with streptococci and only the four that were treated survived. Such simplistic demonstration of a positive...

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  • Long QT syndromes induced by ecstasy and other recreational drugs
    Magí Farre
    Dear Editor

    The recent article by Ghuran and Nolan is a valuable review about cardiovascular effects of recreational drugs.[1] We would like to provide additional information, not included in the review, about the induction of changes in the QT interval by some recreational substances.

    The long QT syndrome has been associated with the occurrence of ventricular tachyarrhythmias (torsades de pointes). Considering the s...

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  • Creatinine kinase rise post partum
    P Rachael James
    Dear Editor

    In the case report by Sutaria et al (Heart 2000;83:97-98) an acute anterior MI complicated the routine administration of ergometrine after a spontaneous vaginal delivery. A peak creatinine kinase (CK) of 9858 U/l was reported (CK-MB fraction 8%) with the apparent implication that this CK rise reflected solely myocardial damage. The myometrium, however, is a source of CK and childbirth results in six fold...

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  • IV and oral flecainide for the cardioversion of acute AF
    Benjamin Mazouz

    Dear Editor

    I read, with great interest the article by Alp et al comparing intravenous and oral flecainide for the cardioversion of acute atrial fibrillation.[1] However, the article concludes that if a patient converts, there is no difference in the percentage of cardioversion by either route (even though the numbers presented tend to favour the oral route). But it fails to mention if there was any differences...

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  • Diagnostic role of BNP not yet established in heart failure
    Martin J Landray
    Dear Editor

    Cowie's editorial envisages a clinical role for measurement of brain natriuretic peptide (BNP) in the near future.[1] However, while the potential for risk stratification and monitoring of treatment in patients with heart failure is encouraging, we would urge caution regarding the diagnostic utility of plasma BNP concentration.

    There is little doubt that the diagnosis of heart failure is difficult -...

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  • A 'Persistent' Problem with Pulmonary Atresia and Intact Ventricular Septum
    Pradeep Vaideeswar

    Dear Editor

    We read with interest the case report by Codispoti et al, depicting an association of pulmonary atresia and intact inter-ventricular septum (PAIS) with persistent pulmonary hypertension of the newborn. In our study of 24 autopsied cases of PAIS, we found four cases (16.7%) with persistence of fetal circulation. All were a few days old with varying degrees of ventricular hypoplasia and tricuspid steno...

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  • Discussion of worldwide perspective of valve disease should include mitral valve prolapse
    Tsung O Cheng
    Dear Editor:

    I enjoyed reading the recent article on the worldwide perspective of valve disease by Soler-Soler and Galve from Barcelona, Spain.[1] But I was surprised that no mention was made of mitral valve prolapse (MVP) anywhere in their article.

    MVP is the commonest valve disorder in the United States as well as in many parts of the world.[2] It also has a prevalence of 4.3% in Spain (see table).

    Prevalence (%...

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  • Coronary Endothelial Dysfunction after Kawasaki Disease
    Yoshihide Mitani
    Dear Editor

    Iemura et al's hypothesis that endothelial dysfunction is associated with coronary aneurysms which have regressed after Kawasaki disease (KD) is interesting[1]; however, there are two issues with respect to their study design that need to be considered, in addition to the issues reported before.[2, 3]

    (1) Is endothelial dysfunction associated with regressed coronary aneurysms per se late after KD?

    ...
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  • Pacing for vasovagal syncope
    Adrian Morley-Davies

    Dear Editor

    Kurbaan and Sutton provide a balanced view of the role of pacing in vasovagal syncope[1] - a common but complex and challenging medical condition.

    However, we feel that attention should be drawn to the methodological problems that bedevil interpretation of the North American Vasovagal Pacemaker Study (VPS).[2] This was not a randomised study of cardiac pacing, but rather a randomised trial...

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