Table of contents

BSCR Autumn Meeting 2014 Abstracts

• 001: TUMOUR NECROSIS FACTOR (TNF-Α) ENHANCES MONOCYTES TRANS-ENDOTHELIAL MIGRATION (TEM) THROUGH GAP JUNCTION (GJ); A ROLE FOR PROTEIN KINASE C (PKC) BUT NOT MAPK (21 November, 2014)

  Ahmed H Qasem, Matt Warner, Christopher H Fry, Rita I Jabr
• 002: CHARACTERIZATION OF DOCOSAHEXAENOIC ACID (A “FISH OIL”) ON VASOMOTOR RESPONSES IN RAT SMALL MESENTERIC RESISTANCE ARTERIES (21 November, 2014)

  R Limbu, AJ McNeish
• 003: NADPH OXIDASE ACTIVATION AND OXIDATIVE STRESS IN HIGH-FAT DIET-INDUCED HYPERTENSION AND METABOLIC DISORDERS (21 November, 2014)

  Anna Mai, Jian-Mei Li
• 004: THE ROLE OF INTIMAL INFLAMMATION AND OXIDATIVE STRESS IN HUMAN VEIN STRUCTURE DAMAGE (21 November, 2014)

  CTD Lee, MS Whiteley, JM Li
• 005: IDENTIFICATION OF NOVEL GENES ASSOCIATED WITH PLATELET ACTIVATION SIGNALLING PATHWAYS IN HIGH DIMENSIONAL DATA USING AN ALTERNATIVE REGRESSION APPROACH (21 November, 2014)

  BR Salehe, LJ McGuffin, CI Jones, G Di Fatta
• 006: ENDOTHELIAL MICROPARTICLES: COMPLEX STRUCTURES THAT HAVE POTENTIAL TO ATTENUATE OSTEOGENIC DIFFERENTIATION OF HUMAN SMOOTH MUSCLE CELLS (21 November, 2014)

  D Moreno-Martinez, FL Wilkinson, B Parker, M Pieri, M Barraclough, I Bruce, MY Alexander
• 007: ELEVATED ENDOTHELIAL MICROPARTICLES IN ASYMPTOMATIC PATIENTS: MARKERS OF UNSTABLE PLAQUES? (21 November, 2014)

  FL Wilkinson, A Schiro, R Weston, JV Smyth, F Serracino-Inglott, MY Alexander
• 008: GENETICS OF INTERLEUKIN 6 AND SELENOPROTEIN S THAT HAVE A ROLE IN INFLAMMATION AND CORONARY ARTERY DISEASE (21 November, 2014)

  H AlHomidani, K Bodman-Smith, A Agouni, FR Green
• 009: THE DIETARY FLAVONOID QUERCETIN MODULATES ENDOTHELIAL NITRIC OXIDE:SUPEROXIDE IMBALANCE VIA EXPRESSION CHANGES IN P47PHOX UNDER HYPERTENSIVE CONDITIONS IN VITRO (21 November, 2014)

  HS Jones, A Gordon, SG Magwenzi, K Naseem, SL Atkin, FL Courts
• 010: STABILISING SUPPRESSOR OF CYTOKINE SIGNALLING 3 (SOCS3) EXPRESSION TO LIMIT NEO-INTIMAL HYPERPLASIA (21 November, 2014)

  Kirsten MA Munro, Jamie JL Williams, David Sumpton, Andrew H Baker, Timothy M Palmer
• 011: TRANSFORMING GROWTH FACTOR BETA DRIVES A DISTINCT DIABETES PHENOTYPE IN HUMAN SAPHENOUS VEIN SMOOTH MUSCLE CELLS VIA UPREGULATION OF MICRORNA-143/145 (21 November, 2014)

  K Riches, IC Wood, NA Turner, KE Porter
• 012: REGULATION OF ACTIN CYTOSKELETON AND FOCAL ADHESION DYNAMICS BY INTERNAL AND EXTERNAL FORCES IN VASCULAR SMOOTH MUSCLE CELLS (21 November, 2014)

  M Pieri, A Mekhalfia, M Platt, J Ohanian, V Ohanian
• 013: HIGH SELENIUM INTAKE IS ASSOCIATED WITH ENDOTHELIAL DYSFUNCTION: CRITICAL ROLE FOR ENDOPLASMIC RETICULUM STRESS (21 November, 2014)

  M Zachariah, MP Rayman, A Agouni
• 014: CAN (-)-EPICATECHIN-RICH MILK CHOCOLATE IMPROVE HUMAN VASCULAR FUNCTION? (21 November, 2014)

  Sophie M Castle, Elena Alañón Pardo, Emily Norris, Jeremy PE Spencer
• 015: STUDYING THE BEHAVIOUR OF PEPITEM ADIPONECTIN MECHANISM ON LYMPHOCYTES MIGRATION IN ATHEROSCLEROSIS PATIENTS (21 November, 2014)

  Mohammed Alassiri, Ed Rainger, Parth Narendran
• 016: HYPOXIA MEDIATED SIGNALLING IN VEIN GRAFT REMODELLING AND FAILURE (21 November, 2014)

  M Huq, S Currie, P Coats
• 017: ROLES FOR A NOVEL CAVIN-1/SOCS3 INTERACTION IN REGULATING PRO-INFLAMMATORY IL-6 SIGNALLING AND CAVEOLA STABILITY (21 November, 2014)

  NA Alotaiq, JJL Williams, TM Palmer
• 018: ENDOTHELIAL-SPECIFIC OVEREXPRESSION OF MUTATED INSULIN-LIKE GROWTH FACTOR-1 RECEPTORS (IGF-1R) ENHANCES ENDOTHELIAL INSULIN SENSITIVITY AND VASCULAR HYDROGEN PEROXIDE GENERATION (21 November, 2014)

  P Shah, H Viswambharan, VK Gatenby, H Imrie, N Haywood, S Galloway, A Sengupta, RM Cubbon, M Gage, A Skromna, N Makova, P Grant, N Yuldasheva, DJ Beech, SB Wheatcroft, MT Kearney
• 019: IMPAIRED ENDOTHELIAL NITRIC OXIDE IS COMPENSATED BY EDHF IN RESISTANCE ARTERIES FROM SUBJECTS WITH PERIPHERAL VASCULAR DISEASE (21 November, 2014)

  P Coats, C Hillier
• 020: ANTHRACYCLINE CARDIOTOXICITY: THE PHARMACOKINETICS AND PHARMACODYNAMICS OF DEXRAZOXANE AND ITS OPEN RING METABOLITE (21 November, 2014)

  A Jirkovska-Vavrova, E Jirkovsky, J Stariat, H Jansova, J Roh, O Lencova-Popelova, P Kovarikova, M Sterba, T Simunek
• 021: UNDERSTANDING THE EFFECTS OF CANCER RADIATION THERAPY ON ENDOTHELIAL CELL DYSFUNCTION – THE ROLE OF NFκB/JNK (21 November, 2014)

  G Hargrave
• 022: STUDY OF MOLECULAR MECHANISMS INVOLVED IN CARDIOPROTECTIVE ACTION OF DEXRAZOXANE AGAINST ANTHRACYCLINE CARDIOTOXICITY IN RABBITS (21 November, 2014)

  E Jirkovsky, O Lencova, A Jirkovska, E Potuckova, M Hroch, M Adamcova, T Simunek, V Gersl, M Sterba
• 023: CAN INORGANIC NITRATE/NITRITE EFFECTIVELY OVERCOME CHRONIC ANTHRACYCLINE CARDIOTOXICITY IN RABBITS? (21 November, 2014)

  O Lencova, E Jirkovsky, Y Mazurova, M Adamcova, J Chladek, M Hroch, T Simunek, V Gersl, M Sterba
• 024: CARDIOTOXICITY OF CHRONIC SUNITINIB TREATMENT IN NORMOTENSIVE AND SPONTANEOUSLY HYPERTENSIVE RATS (21 November, 2014)

  I Nemeckova, O Lencova, E Jirkovsky, M Adamcova, P Nachtigal, M Sterba
• 025: DOES CHEMOTHERAPY HAVE TO BE HEART-BREAKING? (21 November, 2014)

  J W Samways, A W Trafford
• 026: PROTECTIVE EFFECTS OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR)-ß ACTIVATION ON LIPID-INDUCED ENDOTHELIAL DYSFUNCTION via CARNITINE PALMITOYL TRANSFERASE-1 UPREGULATION (21 November, 2014)

  Ayman M Mahmoud, Marta Toral, Miguel Romero, Manuel Gómez-Guzmán, Manuel Sánchez, Julio Gálvez, Francisco Pérez-Vizcaíno, Rosario Jiménez, M Yvonne Alexander, Juan Duarte
• 027: THE DIFFERENTIAL EFFECTS OF SIRTUIN-3 IN CARDIO-PROTECTION (21 November, 2014)

  Andrew R Hall, Sanjeev Kumar, Rachel K Dongworth, Niall Burke, Derek M Yellon, Derek J Hausenloy
• 028: THE NOVEL MITOCHONDRIAL FISSION PROTEINS, MID49 AND MID51: NEW THERAPEUTIC TARGETS FOR CARDIOPROTECTION (21 November, 2014)

  JM Elder, P Samangouei, N Burke, AR Hall, LD Osellame, MT Ryan, DJ Hausenloy
• 029: 3D ELECTRON MICROSCOPY TOMOGRAPHY TO ASSESS MITOCHONDRIAL MORPHOLOGY IN THE ADULT HEART (21 November, 2014)

  S Kalkhoran, AR Hall, A Cole, I White, DM Yellon, DJ Hausenloy
• 030: MITOCHONDRIAL DYNAMICS IN EXPERIMENTAL URAEMIC CARDIOMYOPATHY (21 November, 2014)

  R Atkinson, S Bhandari, AML Seymour
• 031: MITOCHONDRIAL DYSFUNCTION AND OXIDATIVE STRESS IN URAEMIC CARDIOMYOPATHY (21 November, 2014)

  F Nuhu, T Mace, R Sturmey, S Bhandari, AML Seymour
• 032: MITOCHONDRIA MORPHOLOGY AND THE ROLE OF PDE2 IN CARDIAC PATHOPHYSIOLOGY (21 November, 2014)

  S Monterisi, M Zaccolo
• 033: LOSS OF HOMOARGININE IS RESPONSIBLE FOR CARDIAC DYSFUNCTION IN CREATINE-DEFICIENT ARGININE:GLYCINE AMIDINOTRANSFERASE (AGAT) KNOCKOUT MICE (21 November, 2014)

  HJ Whittington, D Atzler, S Zervou, KME Faller, DJ McAndrew, C Choe, D Isbrandt, JE Schneider, S Neubauer, CA Lygate
• 034: THE EFFECTS OF ACUTE AND CHRONIC UP-REGULATION OF PYRUVATE DEHYDROGENASE IN THE HEART (21 November, 2014)

  L Giles, V Ball, DJ Tyler
• 035: THE ROLE OF G-PROTEIN COUPLED RECEPTOR 43 IN HIGH GLUCOSE-INDUCED OXIDATIVE STRESS IN HUMAN BLOOD VESSELS (21 November, 2014)

  Mark J Newton, Maziah Ghazaly, Christopher Lee, Jian-Mei Li
• 036: REDOX-SIGNALLING AND REGULATION OF ENDOTHELIAL CELL CYCLE PROGRESSION AND GPCR43 FUNCTION: THE ROLE OF NADPH OXIDASE 2 (21 November, 2014)

  M Ghazaly, JM Li
• 037: MITOCHONDRIAL REGULATION OF MICRO RNA SYNTHESIS IN VASCULAR SMOOTH MUSCLE CELL PROLIFERATION (21 November, 2014)

  Z Al Sulti, R McDonald, D Kingsmore, A Baker, P Coats
• 038: TIME-RESOLVED AUTOFLUORESCENCE SPECTROSCOPY AS LABEL-FREE METHOD TO CHARACTERISE ACUTE CHANGES IN EX VIVO MODELS OF CARDIAC DISEASE (21 November, 2014)

  BT Dyer, J Lagarto, P French, NS Peters, C Dunsby, AR Lyon
• 039: CHARACTERISING A NOVEL ANTIBODY FOR FULL-LENGTH (ACTIVE) STROMAL DERIVED FACTOR-1α (1–67) (21 November, 2014)

  DI Bromage, DM Yellon, SM Davidson
• 040: GENETIC SILENCING Of PLASMA MEMBRANE CALCIUM ATP-ASE 4 (PMCA4) IN MESENCHYMAL STEM CELLS ENHANCES THE PROTECTIVE EFFECTS AGAINST HYPOXIA (21 November, 2014)

  AB Nugroho, D Oceandy
• 041: COMPARATIVE CHARACTERIZATION OF CARDIAC ATRIAL PROGENITOR CELL POPULATIONS FOR USE IN CELL THERAPY (21 November, 2014)

  S Malandraki-Miller, R Tyser, PR Riley, CA Carr
• 042: TROGLITAZONE INHIBITS VASCULAR SMOOTH MUSCLE CELL PROLIFERATION IN A PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA (PPARγ)-INDEPENDENT MANNER (21 November, 2014)

  Hossam Alkoot, Adam Hargreaves, Abeer Dannoura, Ines Pereira, Alejandro Giraldo-Ramirez, Gavin Brooks, Katrina Bicknell
• 043: THE ROLE OF PHOSPHATASES IN REGULATING GPVI SIGNAL TRANSDUCTION: A SYSTEMS BIOLOGY APPROACH (21 November, 2014)

  Joanne Dunster, Francoise Mazet, Marcus Tindall, Michael J Fry, Jonathan M Gibbins
• 044: AN IMPROVED METHOD FOR THE FRET-BASED DETECTION OF CYCLIC NUCLEOTIDE SIGNALLING IN PRIMARY ADULT MOUSE CARDIOMYOCYTES (21 November, 2014)

  M Brescia, O Lomas, M Zaccolo
• 045: REGULATION OF cAMP SIGNALS AT INDIVIDUAL MACROMOLECULAR COMPLEXES IN CARDIAC MYOCYTES (21 November, 2014)

  NC Surdo, M Berrera, S Pantano, M Zaccolo
• 046: PDI AND ERP57 CO-CLUSTER IN PLATELETS AND THEIR MOVEMENT IS REGULATED BY ACTIN POLYMERIZATION (21 November, 2014)

  M Crescente, FG Pluthero, MP Schenk, MS Ali, WHA Kahr, JM Gibbins
• 047: THE RELATIONSHIP BETWEEN THE METABOLITES OF THE DIETARY FLAVONOID QUERCETIN AND HAEMOSTASIS, THROMBOSIS AND PLATELET FUNCTION (21 November, 2014)

  AR Stainer, JA Lovegrove, JM Gibbins
• 048: CALCIUM/CALMODULIN DEPENDENT PROTEIN KINASE II δ MODULATES INTRACELLULAR Ca2+ RELEASE AND CELL PROLIFERATION IN ADULT CARDIAC FIBROBLASTS (21 November, 2014)

  M Mohd Salleh, C McCluskey, T Bushell, S Currie
• 049: EXPRESSION OF TYPE 2A PROTEIN PHOSPHATASES IN CARDIAC HEALTH AND DISEASE (21 November, 2014)

  O Eleftheriadou, MR Longman, A Boguslavskyi, A Ryan, BE Wadzinski, MJ Shattock, AK Snabaitis
• 050: A NOVEL ROLE OF PLASMA MEMBRANE CALCIUM ATPASE 4 AS A NEGATIVE-REGULATOR OF VEGF-INDUCED ANGIOGENESIS (21 November, 2014)

  RR Baggott, A Alfranca, MD López-Maderuelo, TMA Mohamed, A Escolano, J Oller, BC Ornés, FB Rowther, D Oceandy, S Kurusamy, J Brown, EJ Cartwright, W Wang, P Gómez-Del Arco, S Martínez-Martínez, L Neyses, JM Redondo, AL Armesilla
• 051: CONTROL OF ATRIAL GAP JUNCTION CONDUCTANCE BY INTRACELLULAR PHOSPHATASES (21 November, 2014)

  FS Hatch, A Waheed, SC Salvage, CH Fry, RI Jabr
• 052: CONTROL OF GAP JUNCTION CONDUCTANCE BY CALCINEURIN-DEPENDENT CX-43 PHOSPHORYLATION: IMPLICATIONS OF ARRHYTHMOGENESIS (21 November, 2014)

  A Waheed, PD Lampe, SC Salvage, FS Hatch, CH Fry, RI Jabr
• 053: GAP JUNCTIONS AND CONNEXIN HEMICHANNELS UNDERPIN HAEMOSTASIS AND THROMBOSIS (21 November, 2014)

  S Vaiyapuri, CI Jones, P Sasikumar, LA Moraes, MS Ali, T Sage, AM Simon, M Mahaut-Smith, JM Gibbins
• 054: ELUCIDATING THE ROLE OF P38γ IN PATHOLOGICAL CARDIAC HYPERTROPHY (21 November, 2014)

  Aminah Loonat, Francesca Hunt, Sang Hoon Choi, E Denise Martin, Nicholas T Hertz, Becca Levin, Kevan M Shokat, Alma L Burlingame, Michael S Marber, James E Clark
• 055: CARDIAC ARTERIAL SPIN LABELLING MRI AS A NOVEL APPROACH FOR IN VIVO QUANTIFICATION OF THE AREA-AT-RISK (21 November, 2014)

  RK Dongworth, AE Campbell-Washburn, T Roberts, DM Yellon, MF Lythgoe, DJ Hausenloy
• 056: NOVEL NESPRIN-1 MUTATIONS DISRUPT NE ORGANIZATION AND INDUCE DILATED CARDIOMYOPATHY (21 November, 2014)

  C Zhou, C Li, B Zhou, L Rao, EM McNally, CM Shanahan, QP Zhang
• 057: INCREASED PASSIVE AND CONTRACTILE STRESS WITHIN THE MYOFILAMENTS CONTRIBUTE TO THE LOSS OF MECHANOSENSING IN THE HEART DURING THE PROGRESSION TO HEART FAILURE (21 November, 2014)

  A Paudyal, S Dewan, P De Tombe, S Boateng
• 058: A TRANSGENIC APPROACH TO STUDY THE EFFECT OF CARDIAC FIBROBLAST-SPECIFIC ABLATION OF IL-1 SIGNALLING ON MYOCARDIAL REMODELLING (21 November, 2014)

  KE Hemmings, SA Bageghni, KE Porter, MJ Drinkhill, JFX Ainscough, NA Turner
• 059: MAPPING REGIONAL REPOLARISATION GRADIENTS IN THE FAILING HUMAN VENTRICLE USING CARDIAC SLICES (21 November, 2014)

  P Camelliti, S Al-Ayoubi, C Terracciano
• 060: MAP4K4 MEDIATES CARDIOMYOCYTE CELL DEATH AND POTENTIATES A HEART FAILURE PHENOTYPE (21 November, 2014)

  LR Fiedler, M Jenkins, E Maifoshie, M Harada, DJ Stuckey, W Song, R Sampson, SE Harding, MD Schneider
• 061: TARGETING THE INTERACTION BETWEEN P38MAPK AND TAB1 (21 November, 2014)

  Dibesh Thapa, Gian De Nicola, Michael Marber
• 062: CLONING AND CHARACTERISATION OF A 1233-RESIDUE MITOGEN-ACTIVATED KINASE KINASE KINASE KINASE 4 (MAP4K4) FROM RAT CARDIOMYOCYTES (21 November, 2014)

  SJ Fuller, A Clerk, PH Sugden
• 063: EPAC IS A KEY MEDIATOR OF cAMP-INDUCED CARDIOPROTECTIVE SIGNALLING (21 November, 2014)

  I Khaliulin, M Bond, MS Suleiman
• 064: PARADOXICAL DEPHOSPHORYLATION OF CARDIAC HISTONE DEACETYLASE 5 BY BETA-ADRENERGIC STIMULATION (21 November, 2014)

  KL Weeks, H Lewis, A Karas, AS Ashcroft, SL Puhl, M Avkiran
• 065: NAADP AS A NOVEL DOWNSTREAM MEDIATOR OF CARDIAC BETA-ADRENERGIC PATHWAY (21 November, 2014)

  WK Lin, E Bolton, R Capel, A Galione, DA Terrar
• 066: ALTERED GLYCOSYLATION AND DISTRIBUTION OF THE β2 ADRENOCEPTOR IN HEART FAILURE (21 November, 2014)

  R Norman, M Drinkhill, J Deuchars, S Calaghan
• 067: EXOGENOUS LYSOPHOSPHATIDOLINOSITOL EXACERBATES MYOCARDIAL TISSUE INJURY VIA A GPR55 DEPENDENT MECHANISM (21 November, 2014)

  OJ Robertson-Gray, SK Walsh, AC Jönsson-Rylander, CL Wainwright
• 068: THE ADULT MURINE HEART IS PROTECTED AGAINST ISCHEMIA-REPERFUSION INJURY IN THE ABSENCE OF BOTH MITOFUSIN (MFN) PROTEINS (21 November, 2014)

  Andrew R Hall, Niall Burke, Rachel K Dongworth, Yun Chen, Gerald W Dorn, Derek J Hausenloy
• 069: EXPRESSION AND ACTIVATION OF CARDIAC PROTEIN KINASES N1 AND N2 (PKN1/2) (21 November, 2014)

  S Osborne, SJ Fuller, PH Sugden, A Clerk
• 070: DISSECTING THE ROLES OF MITOGEN-ACTIVATED PROTEIN KINASE (MAPK) CASCADES IN THE MRNA EXPRESSION RESPONSE TO H2O2 IN CARDIOMYOCYTES (21 November, 2014)

  SJ Leonard, PH Sugden, A Clerk
• 071: GPR55 EXERTS DIFFERENTIAL EFFECTS ON CARDIAC ADRENOCEPTOR SUBTYPES IN MICE (21 November, 2014)

  SK Walsh, CL Wainwright
• 072: THE PLASMA MEMBRANE CALCIUM ATPASE 4 SPECIFIC INHIBITOR AURINTRICARBOXYLIC ACID ENHANCES VEGF-INDUCED ANGIOGENESIS (21 November, 2014)

  S Kurusamy, RR Baggott, MD López-Maderuelo, V Kannappan, A Escolano, J Oller, R Little, SJ Dunmore, D Oceandy, EJ Cartwright, W Wang, L Neyses, JM Redondo, AL Armesilla