Article Text
Abstract
Objective To investigate the drug effects of Shengmai Injection (SMI) on blood vascular endodermis function and cardiac function in coronary artery disease (CAD) with type 2 diabetes mellitus (2-DM) patients.
Methods A total of 120 patients with type 2 diabetes mellitus and CAD diagnosed by coronary angiography (CAG) were randomised into two groups, the control group, treated with conventional therapy and the SMI group, treated with SMI. The patients ’ nitrite oxide (NO), Endothelin-1 (ET-1), AngII in venous blood were noted, and the blood vascular endodermis function, cardiac function were measured before treatment and after 3 weeks treatment, so as to observe and compare their changes in the two groups.
Results After 3 weeks of treatment, the serum content of NO was significantly higher, the serum content of ET-1 and AngII were significantly lower in the SMI group than that in the control group (p<0.01); The patients’ blood vascular endodermis function and cardiac function were improved in SMI group than that in the control group (p<0.01).
Conclusion The SMI could not only improve the blood vascular endodermis function but also improve the cardiac function in coronary artery disease with type 2 diabetes mellitus patients.
- Shengmai Injection (SMI)
- coronary artery disease (CAD))
- type 2 diabetes
- blood vascular endodermis function
- cardiac function Key words Shengmai Injection (SMI)
- coronary artery disease (CAD))
- type 2 diabetes
- blood vascular endodermis function
- cardiac function