Footnotes

• Contributors I conceived and designed the work, drafted the article, critically revised the article and provided final approval for publication.

• Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

• Competing interests KWZ reports personal fees from Eidos Therapeutics, outside the submitted work.

• Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.

• Patient consent for publication Not required.

• Provenance and peer review Commissioned; internally peer reviewed.