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The Authors' reply: We thank Professor Hippisley-Cox and colleagues1 for their comments on our paper.2 We agree that our study has limitations, but consider that we have stated these clearly within the manuscript. We believe that, notwithstanding these limitations, we bring new information regarding the performance of these widely used cardiovascular risk scores in three British ethnic groups. Importantly, these analyses were conducted independently of the authors of QRISK2 and Framingham risk scores and we report ethnicity-specific findings. Our take-home messages are that these risk scores performed differently and only modestly in the SABRE cohort in identifying individuals at high risk who would later go on to suffer events (particularly in South Asian women and in African Caribbean men and women). We suggest that further independent validation in other multiethnic data sets would be helpful.
With regard to specific comments, our responses are below:
We agree that numbers of events were few in women, and indeed in African Caribbeans of both sexes—for this reason we urged caution in interpretation of the findings in these groups under ‘strengths and …
Contributors TT wrote the first draft of the this response letter. All coauthors reviewed and contributed to the final version.
Competing interests None.
Ethics approval Baseline: Ealing, Hounslow and Spelthorne and University College London research ethics committees. Follow-up@ St Mary's Hospital research ethics committee (ref. 07/H0712/109).
Provenance and peer review Not commissioned; internally peer reviewed.
Data sharing statement Data will be deposited with the UK Data Archive in 2014.